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mutLBSgeneDB |
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| Gene summary for CDC25B |
 Gene summary |
| Basic gene Info. | Gene symbol | CDC25B |
| Gene name | cell division cycle 25B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 20p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001287516.1, NM_001287517.1,NM_001287518.1,NM_001287519.1,NM_001287520.1, NM_001287522.1,NM_001287524.1,NM_004358.4,NM_021872.3, NM_021873.3,NM_021874.2,NM_212530.1, | |
| Description | M-phase inducer phosphatase 2dual specificity phosphatase Cdc25B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 116949 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101224 | ||
| HPRD : 00307 | ||
| Vega : OTTHUMG00000031764 | ||
| Protein | UniProt: P30305 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDC25B | |
| BioGPS: 994 | ||
| Pathway | NCI Pathway Interaction Database: CDC25B | |
| KEGG: CDC25B | ||
| REACTOME: CDC25B | ||
| Pathway Commons: CDC25B | ||
| Context | iHOP: CDC25B | |
| ligand binding site mutation search in PubMed: CDC25B | ||
| UCL Cancer Institute: CDC25B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 17332740 |
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| Ligand binding site mutations for CDC25B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M519 | Y520H | COAD | 1 | C498 | R496H | SKCM | 1 | R506 | R506H | STAD | 1 | F489 | F489L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CDC25B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R506 | R506H | -1.339121 | C498 | R496H | -0.97681185 | F489 | F489L | -0.56097111 | M519 | Y520H | -0.39986866 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CDC25B from PDB |
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| Differential gene expression and gene-gene network for CDC25B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CDC25B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CDC25B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01769 | Double Oxidized Cysteine | Small molecule |  |
| Experimental | DB03661 | Cysteinesulfonic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CDC25B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CDC25B |
| Multiple alignments for P30305 in multiple species |
| LBS | AA sequence | # species | Species | C487 | ILIFHCEFSSE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C498 | RGPRMCRFIRE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D411 | DGKHQDLKYIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E460 | VNLPLERDAES | 1 | Homo sapiens | E460 | VNLPLERDAET | 1 | Mus musculus | E460 | VNLPLEPDAET | 1 | Rattus norvegicus | E488 | LIFHCEFSSER | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E492 | CEFSSERGPRM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F489 | IFHCEFSSERG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L412 | GKHQDLKYISP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L459 | AVNLPLERDAE | 2 | Homo sapiens, Mus musculus | L459 | AVNLPLEPDAE | 1 | Rattus norvegicus | M519 | LYYPEMYILKG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R493 | EFSSERGPRMC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R499 | GPRMCRFIRER | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R502 | MCRFIRERDRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R506 | IRERDRAANDY | 2 | Mus musculus, Rattus norvegicus | R506 | IRERDRAVNDY | 1 | Homo sapiens | R562 | FRLKTRSWAGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S490 | FHCEFSSERGP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S491 | HCEFSSERGPR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T561 | NFRLKTRSWAG | 2 | Mus musculus, Rattus norvegicus | T561 | TFRLKTRSWAG | 1 | Homo sapiens |
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