mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for CDC42

Gene summary

Basic gene Info.	Gene symbol	CDC42
	Gene name	cell division cycle 42
	Synonyms	CDC42Hs\|G25K
	Cytomap	UCSC genome browser: 1p36.1
	Type of gene	protein-coding
	RefGenes	NM_001039802.1, NM_001791.3,NM_044472.2,
	Description	G25K GTP-binding proteinGTP binding protein, 25kDaGTP-binding protein, 25kDcell division control protein 42 homologdJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))growth
	Modification date	20141207
dbXrefs	MIM : 116952
	HGNC : HGNC
	Ensembl : ENSG00000070831
	HPRD : 00309
	Vega : OTTHUMG00000002753
Protein	UniProt: P60953 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CDC42
	BioGPS: 998
Pathway	NCI Pathway Interaction Database: CDC42
	KEGG: CDC42
	REACTOME: CDC42
	Pathway Commons: CDC42
Context	iHOP: CDC42
	ligand binding site mutation search in PubMed: CDC42
	UCL Cancer Institute: CDC42
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0030036	actin cytoskeleton organization	11035016
GO:0031274	positive regulation of pseudopodium assembly	11035016
GO:0051489	regulation of filopodium assembly	14978216
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	11807099

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Ligand binding site mutations for CDC42

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
A41	A41T	HNSC	1
D57	T58A	KIRC	1
E31,P29	S30L	LAML	1
L67	D65V	SKCM	1
Q61	D63V	THCA	1
Q61	E62D	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for CDC42

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E31	S30L	0.15506155
P29	S30L	0.15506155
A41	A41T	-1.1802187
D57	T58A	-0.98647703
Q61	D63V	-0.78912676
Q61	E62D	-0.64952694
L67	D65V	-0.23151286

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDC42 from PDB

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Differential gene expression and gene-gene network for CDC42

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of CDC42 and the right PPI network was created from samples without mutations in the LBS of CDC42. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for CDC42

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0019693	HIV Infections	5	AlteredExpression, Biomarker, GeneticVariation
umls:C0007097	Carcinoma	4	Biomarker
umls:C0001624	Adrenal Gland Neoplasms	1	Biomarker
umls:C0024667	Mammary Neoplasms, Animal	1	Biomarker
umls:C0024668	Mammary Neoplasms, Experimental	1	Biomarker
umls:C0027540	Necrosis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for CDC42

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB02623	Aminophosphonic Acid-Guanylate Ester	Small molecule
Experimental	DB04315	Guanosine-5'-Diphosphate	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDC42 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (SER,ASN,LEU,VAL,ILE,SER,ASP,PRO,ILE,PRO,GLY,ALA,LYS,PRO,LEU,PRO,VAL,PRO,PRO,GLU,LEU,ALA,PRO,PHE,VAL,GLY,ARG,MET,SER)	4js0	A	A41 L67
MG		MAGNESIUM(2+)	1a4r	A	D57
MG		MAGNESIUM(2+)	1doa	A	D57
MG		MAGNESIUM(2+)	2qrz	A	D57
MG		MAGNESIUM(2+)	4ydh	B	D57
MG		MAGNESIUM(2+)	4ydh	D	D57
GNP		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	1cf4	A	E31
GNP		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	1e0a	A	P29
AF3		ALUMINIUM TRIFLUORIDE	1grn	A	Q61
AF3		ALUMINIUM TRIFLUORIDE	2ngr	A	Q61
GCP		5'-GUANYLYLMETHYLENEBISPHOSPHONATE	2qrz	A	Q61
GCP		5'-GUANYLYLMETHYLENEBISPHOSPHONATE	2qrz	B	Q61
GTP		GTP	2wmo	B	Q61

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Conservation information for LBS of CDC42

Multiple alignments for P60953 in multiple species

LBS	AA sequence	# species	Species
A13	VVGDGAVGKTC	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
A13	TVGDGAVGKTC	1	Oryza sativa subsp. japonica
A159	YVECSALTQKG	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A159	YVECSALTQRG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A159	YIECSSKTQRN	1	Oryza sativa subsp. japonica
A41	VFDNYAVTVMI	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
A41	VFDNFSANVSV	1	Oryza sativa subsp. japonica
C157	VKYVECSALTQ	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
C157	VAYIECSSKTQ	1	Oryza sativa subsp. japonica
C18	AVGKTCLLISY	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
C18	AVGKTCMLICY	1	Oryza sativa subsp. japonica
C6	MQTIKCVVVGD	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
C6	MQTLKCVVVGD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C6	TRFIKCVTVGD	1	Oryza sativa subsp. japonica
C6	MPTIKCVVVGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C81	DVFLVCFSVVS	6	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C81	DVFILSFSLIS	1	Oryza sativa subsp. japonica
C81	DVFLVCFSVVA	1	Caenorhabditis elegans
C81	DVFLVCFSVTS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C81	DVFLVCFSVIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D11	CVVVGDGAVGK	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
D11	CVTVGDGAVGK	1	Oryza sativa subsp. japonica
D118	VGTQIDLRDDP	5	Homo sapiens, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D118	VGTKLDLREDR	1	Oryza sativa subsp. japonica
D118	VGTQVDLRDDP	1	Caenorhabditis elegans
D118	VGTQIDLRDEN	1	Anopheles gambiae
D118	VGTQIDLRDDK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D118	VGTQIDLRENK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D170	LKNVFDEAILA	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
D170	LKNVFDEAIVA	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D170	IKAVFDTAIKV	1	Oryza sativa subsp. japonica
D38	VPTVFDNYAVT	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
D38	IPTVFDNFSAN	1	Oryza sativa subsp. japonica
D57	TLGLFDTAGQE	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
D57	NLGLWDTAGQE	1	Oryza sativa subsp. japonica
E156	AVKYVECSALT	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
E156	AVAYIECSSKT	1	Oryza sativa subsp. japonica
E31	NKFPSEYVPTV	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
E31	NQFPADYVPTV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E31	NKFPTDYIPTV	1	Oryza sativa subsp. japonica
E31	NKFPSDYVPTV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F28	YTTNKFPSEYV	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
F28	YTTNQFPADYV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F28	YTCNKFPTDYI	1	Oryza sativa subsp. japonica
F28	YTTNKFPSDYV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F37	YVPTVFDNYAV	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
F37	YIPTVFDNFSA	1	Oryza sativa subsp. japonica
F56	YTLGLFDTAGQ	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
F56	VNLGLWDTAGQ	1	Oryza sativa subsp. japonica
F82	VFLVCFSVVSP	6	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F82	VFILSFSLISR	1	Oryza sativa subsp. japonica
F82	VFLVCFSVVAP	1	Caenorhabditis elegans
F82	VFLVCFSVTSP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F82	VFLVCFSVISP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G114	PFLLVGTQIDL	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
G114	PCLIVGTQIDL	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G114	PVVLVGTKLDL	1	Oryza sativa subsp. japonica
G114	PFLLVGTQVDL	1	Caenorhabditis elegans
G114	PCLVVGTQIDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G12	VVVGDGAVGKT	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
G12	VTVGDGAVGKT	1	Oryza sativa subsp. japonica
G15	GDGAVGKTCLL	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
G15	GDGAVGKTCML	1	Oryza sativa subsp. japonica
G47	VTVMIGGEPYT	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
G47	VTVMIGDEPYT	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G47	ANVSVDGSVVN	1	Oryza sativa subsp. japonica
G54	EPYTLGLFDTA	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
G54	SVVNLGLWDTA	1	Oryza sativa subsp. japonica
G60	LFDTAGQEDYD	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
G60	LWDTAGQEDYS	1	Oryza sativa subsp. japonica
I117	LVGTQIDLRDD	4	Homo sapiens, Canis lupus familiaris, Bos taurus, Gallus gallus
I117	LVGTKLDLRED	1	Oryza sativa subsp. japonica
I117	LVGTQVDLRDD	1	Caenorhabditis elegans
I117	LVGTQIDLRDE	1	Anopheles gambiae
I117	IVGTQIDLRDD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I117	VVGTQIDLRDD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I117	IVGTQIDLREN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I173	VFDEAILAALE	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
I173	VFDEAIVAALE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I173	VFDTAIKVVLQ	1	Oryza sativa subsp. japonica
I173	VFDEAILAALD	1	Caenorhabditis elegans
I173	VFDEAIVAALD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I21	KTCLLISYTTN	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
I21	KTCMLICYTCN	1	Oryza sativa subsp. japonica
I4	--MQTIKCVVV	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
I4	--MQTLKCVVV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I4	AATRFIKCVTV	1	Oryza sativa subsp. japonica
I4	--MPTIKCVVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I46	AVTVMIGGEPY	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
I46	AVTVMIGDEPY	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I46	SANVSVDGSVV	1	Oryza sativa subsp. japonica
K16	DGAVGKTCLLI	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
K16	DGAVGKTCMLI	1	Oryza sativa subsp. japonica
K166	TQKGLKNVFDE	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K166	TQRGLKNVFDE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K166	TQRNIKAVFDT	1	Oryza sativa subsp. japonica
K5	-MQTIKCVVVG	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
K5	-MQTLKCVVVG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K5	ATRFIKCVTVG	1	Oryza sativa subsp. japonica
K5	-MPTIKCVVVG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L119	GTQIDLRDDPS	5	Homo sapiens, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L119	GTKLDLREDRA	1	Oryza sativa subsp. japonica
L119	GTQVDLRDDPG	1	Caenorhabditis elegans
L119	GTQIDLRDENS	1	Anopheles gambiae
L119	GTQIDLRDDKV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L119	GTQIDLRENKM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L160	VECSALTQKGL	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L160	VECSALTQRGL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L160	IECSSKTQRNI	1	Oryza sativa subsp. japonica
L165	LTQKGLKNVFD	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L165	LTQRGLKNVFD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L165	KTQRNIKAVFD	1	Oryza sativa subsp. japonica
L174	FDEAILAALEP	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
L174	FDEAIVAALEP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L174	FDTAIKVVLQP	1	Oryza sativa subsp. japonica
L174	FDEAILAALDP	1	Caenorhabditis elegans
L174	FDEAIVAALDP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L19	VGKTCLLISYT	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
L19	VGKTCMLICYT	1	Oryza sativa subsp. japonica
L67	EDYDRLRPLSY	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
L67	EDYSRLRPLSY	1	Oryza sativa subsp. japonica
L70	DRLRPLSYPQT	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L70	DRLRPLSYPST	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L70	SRLRPLSYRGA	1	Oryza sativa subsp. japonica
M45	YAVTVMIGGEP	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
M45	YAVTVMIGDEP	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M45	FSANVSVDGSV	1	Oryza sativa subsp. japonica
N26	ISYTTNKFPSE	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
N26	ISYTTNQFPAD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N26	ICYTCNKFPTD	1	Oryza sativa subsp. japonica
N26	ISYTTNKFPSD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N39	PTVFDNYAVTV	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
N39	PTVFDNFSANV	1	Oryza sativa subsp. japonica
P29	TTNKFPSEYVP	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
P29	TTNQFPADYVP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P29	TCNKFPTDYIP	1	Oryza sativa subsp. japonica
P29	TTNKFPSDYVP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P34	PSEYVPTVFDN	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
P34	PADYVPTVFDN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P34	PTDYIPTVFDN	1	Oryza sativa subsp. japonica
P34	PSDYVPTVFDN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q116	LLVGTQIDLRD	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
Q116	VLVGTKLDLRE	1	Oryza sativa subsp. japonica
Q116	LLVGTQVDLRD	1	Caenorhabditis elegans
Q116	LIVGTQIDLRD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q116	LVVGTQIDLRD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q116	LIVGTQIDLRE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q162	CSALTQKGLKN	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q162	CSALTQRGLKN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q162	CSSKTQRNIKA	1	Oryza sativa subsp. japonica
Q61	FDTAGQEDYDR	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
Q61	WDTAGQEDYSR	1	Oryza sativa subsp. japonica
R186	EPKKSRR-CVL	3	Homo sapiens, Canis lupus familiaris, Bos taurus
R186	RHKDVTR-KKL	1	Oryza sativa subsp. japonica
R186	QQEKKKK-CNI	1	Caenorhabditis elegans
R186	EPTKKRK-CRF	1	Anopheles gambiae
R186	EPKKTRR-CVL	1	Gallus gallus
R186	VPHKKKSKCLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R186	VIKKSKK-CAI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R186	VIKKSKK-CTI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S158	KYVECSALTQK	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S158	KYVECSALTQR	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S158	AYIECSSKTQR	1	Oryza sativa subsp. japonica
S22	TCLLISYTTNK	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S22	TCLLISYTTNQ	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S22	TCMLICYTCNK	1	Oryza sativa subsp. japonica
S71	RLRPLSYPQTD	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S71	RLRPLSYPSTD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S71	RLRPLSYRGAD	1	Oryza sativa subsp. japonica
S83	FLVCFSVVSPS	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
S83	FILSFSLISRA	1	Oryza sativa subsp. japonica
S83	FLVCFSVVAPA	1	Caenorhabditis elegans
S83	FLVCFSVTSPA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S83	FLVCFSVISPP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S83	FLVCFSVVSPP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T115	FLLVGTQIDLR	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
T115	CLIVGTQIDLR	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T115	VVLVGTKLDLR	1	Oryza sativa subsp. japonica
T115	FLLVGTQVDLR	1	Caenorhabditis elegans
T115	CLVVGTQIDLR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T161	ECSALTQKGLK	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T161	ECSALTQRGLK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T161	ECSSKTQRNIK	1	Oryza sativa subsp. japonica
T17	GAVGKTCLLIS	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
T17	GAVGKTCMLIC	1	Oryza sativa subsp. japonica
T3	---MQTIKCVV	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
T3	---MQTLKCVV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T3	AAATRFIKCVT	1	Oryza sativa subsp. japonica
T3	---MPTIKCVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T35	SEYVPTVFDNY	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
T35	ADYVPTVFDNY	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T35	TDYIPTVFDNF	1	Oryza sativa subsp. japonica
T35	SDYVPTVFDNY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T43	DNYAVTVMIGG	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
T43	DNYAVTVMIGD	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T43	DNFSANVSVDG	1	Oryza sativa subsp. japonica
T52	GGEPYTLGLFD	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
T52	GDEPYTLGLFD	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T52	DGSVVNLGLWD	1	Oryza sativa subsp. japonica
V113	TPFLLVGTQID	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
V113	VPCLIVGTQID	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V113	VPVVLVGTKLD	1	Oryza sativa subsp. japonica
V113	TPFLLVGTQVD	1	Caenorhabditis elegans
V113	VPCLVVGTQID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V14	VGDGAVGKTCL	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
V14	VGDGAVGKTCM	1	Oryza sativa subsp. japonica
V33	FPSEYVPTVFD	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
V33	FPADYVPTVFD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V33	FPTDYIPTVFD	1	Oryza sativa subsp. japonica
V33	FPSDYVPTVFD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V36	EYVPTVFDNYA	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
V36	DYVPTVFDNYA	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V36	DYIPTVFDNFS	1	Oryza sativa subsp. japonica
V42	FDNYAVTVMIG	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
V42	FDNFSANVSVD	1	Oryza sativa subsp. japonica
V44	NYAVTVMIGGE	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
V44	NYAVTVMIGDE	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V44	NFSANVSVDGS	1	Oryza sativa subsp. japonica
V84	LVCFSVVSPSS	5	Homo sapiens, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
V84	ILSFSLISRAS	1	Oryza sativa subsp. japonica
V84	LVCFSVVAPAS	1	Caenorhabditis elegans
V84	LVCFSVTSPAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V84	LVCFSVISPPS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V84	LVCFSVVSPPS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y23	CLLISYTTNKF	7	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y23	CLLISYTTNQF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y23	CMLICYTCNKF	1	Oryza sativa subsp. japonica
Y32	KFPSEYVPTVF	6	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus
Y32	QFPADYVPTVF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y32	KFPTDYIPTVF	1	Oryza sativa subsp. japonica
Y32	KFPSDYVPTVF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y40	TVFDNYAVTVM	9	Homo sapiens, Caenorhabditis elegans, Anopheles gambiae, Canis lupus familiaris, Bos taurus, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CB
Y40	TVFDNFSANVS	1	Oryza sativa subsp. japonica