| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K1M2 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000071898 |
| Ensembl nucleotide ID | ENSRNOG00000038597 |
| Gene name | Disks large homolog 1 |
| Gene symbol | Dlg1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVISI FQSNLFQALI DIQEFYEVTL 60 LDNPKCVDHS KQCEPVQPGN PWESGSLSSA AVTSESLPGG LSPPVEKYRY QDEEVLPSER 120 ISPQVPNEVL GPELVHVSEK SLSEIENVHG FVSHSHISPI KPTEAVPPSS PIVPVTPALP 180 VPAESPVVLP STPQANPPPV LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG 240 GTDNPHIGDD SSIFITKIIT GGAAAQDGRL RVNDCILRVN EADVRDVTHS KAVEALKEAG 300 SIVRLYVKRR KPASEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV TKIIEGGAAH 360 KDGKLQIGDK LLAVNSVCLE EVTHEEAVTA LKNTSDFVYL KVAKPTSMYI NDGYAPPDIT 420 NSSSQSVDNH VSPSSYLGQT PASPARYSPI SKAVLGDDEI TREPRKVVLH RGSTGLGFNI 480 VGGEDGEGIF ISFILAGGPA DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT 540 IVAQYRPEEY SRFEAKIHDL REQMMNSSVS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 600 PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK ERARLKTVKF 660 NSKTRGDKGE IPDDMGSKGL KHVTSNASDS ESSYLILITD EYGCSKGGQE EYVLSYEPVN 720 QQEVNYTRPV IILGPMKDRV NDDLISEFPD KFGSCVPHTT RPKRDYEVDG RDYHFVTSRE 780 QMEKDIQEHK FIEAGQYNNH LYGTSVQSVR AVAEKGKHCI LDVSGNAIKR LQIAQLYPIS 840 IFIKPKSMEN IMEMNKRLTD EQARKTFERA VRLEQEFTEH FTAIVQGDTL EDIYNQVKQI 900 IEEQSGPYIW VPAKEKL 917 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLG1 | A0A452E2Y8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DLG1 | 1739 | Q12959 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dlg1 | 13383 | Q811D0 | CPO | E12.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DLG1 | K7C1N7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Dlg1 | A0A0G2K1M2 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | dlg1 | 114446 | Q5PYH6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0016323 | basolateral plasma membrane |
| GO:0005923 | bicellular tight junction |
| GO:0005623 | cell |
| GO:0031253 | cell projection membrane |
| GO:0009898 | cytoplasmic side of plasma membrane |
| GO:0005783 | endoplasmic reticulum |
| GO:0098978 | glutamatergic synapse |
| GO:0005794 | Golgi apparatus |
| GO:0001772 | immunological synapse |
| GO:0043219 | lateral loop |
| GO:0016328 | lateral plasma membrane |
| GO:0045121 | membrane raft |
| GO:0005874 | microtubule |
| GO:0097025 | MPP7-DLG1-LIN7 complex |
| GO:0035748 | myelin sheath abaxonal region |
| GO:0031594 | neuromuscular junction |
| GO:0033268 | node of Ranvier |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0014069 | postsynaptic density |
| GO:0097060 | synaptic membrane |
| GO:0044325 | ion channel binding |
| GO:0097016 | L27 domain binding |
| GO:0031434 | mitogen-activated protein kinase kinase binding |
| GO:0060090 | molecular adaptor activity |
| GO:0019902 | phosphatase binding |
| GO:0015459 | potassium channel regulator activity |
| GO:0008022 | protein C-terminus binding |
| GO:0098919 | structural constituent of postsynaptic density |
| GO:0007015 | actin filament organization |
| GO:0032147 | activation of protein kinase activity |
| GO:0042982 | amyloid precursor protein metabolic process |
| GO:0030953 | astral microtubule organization |
| GO:0070830 | bicellular tight junction assembly |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0098609 | cell-cell adhesion |
| GO:0034629 | cellular protein-containing complex localization |
| GO:0030866 | cortical actin cytoskeleton organization |
| GO:0043622 | cortical microtubule organization |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0001935 | endothelial cell proliferation |
| GO:0051660 | establishment of centrosome localization |
| GO:0060022 | hard palate development |
| GO:0001771 | immunological synapse formation |
| GO:0002088 | lens development in camera-type eye |
| GO:0031579 | membrane raft organization |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0045930 | negative regulation of mitotic cell cycle |
| GO:1903753 | negative regulation of p38MAPK cascade |
| GO:0051898 | negative regulation of protein kinase B signaling |
| GO:0042130 | negative regulation of T cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| GO:0030432 | peristalsis |
| GO:0030838 | positive regulation of actin filament polymerization |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0043268 | positive regulation of potassium ion transport |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0072659 | protein localization to plasma membrane |
| GO:0008360 | regulation of cell shape |
| GO:0031641 | regulation of myelination |
| GO:1903764 | regulation of potassium ion export across plasma membrane |
| GO:1903286 | regulation of potassium ion import |
| GO:1902473 | regulation of protein localization to synapse |
| GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| GO:0048608 | reproductive structure development |
| GO:0048745 | smooth muscle tissue development |
| GO:0042110 | T cell activation |
| GO:0002369 | T cell cytokine production |
| InterPro ID | InterPro Term |
|---|---|
| IPR016313 | DLG1-like |
| IPR019590 | DLG1_PEST_dom |
| IPR008145 | GK/Ca_channel_bsu |
| IPR008144 | Guanylate_kin-like_dom |
| IPR020590 | Guanylate_kinase_CS |
| IPR015143 | L27_1 |
| IPR004172 | L27_dom |
| IPR036892 | L27_dom_sf |
| IPR027417 | P-loop_NTPase |
| IPR001478 | PDZ |
| IPR019583 | PDZ_assoc |
| IPR036034 | PDZ_sf |
| IPR036028 | SH3-like_dom_sf |
| IPR001452 | SH3_domain |