| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3TNT6; A0A2J8NM67; |
| Entrez ID | 100608531 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_009441951.2 |
| Ensembl protein ID | ENSPTRP00000090911 |
| Ensembl nucleotide ID | ENSPTRG00000045174 |
| Gene name | Transcription factor SOX |
| Gene symbol | SOX11 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 60 KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 120 RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA 180 GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DEEELQLQIK 240 QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 300 ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD 360 LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE 420 LSEMIAGDWL EANFSDLVFT Y 441 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOX11 | A0A452FZZ0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SOX11 | 6664 | P35716 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sox11 | 20666 | Q7M6Y2 | CPO,CLP | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SOX11 | 100608531 | A0A2I3TNT6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SOX11 | 100514639 | F1S9L1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Sox11 | 84046 | P0C1G9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0044798 | nuclear transcription factor complex |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0003211 | cardiac ventricle formation |
| GO:0030154 | cell differentiation |
| GO:0061386 | closure of optic fissure |
| GO:0061303 | cornea development in camera-type eye |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0021782 | glial cell development |
| GO:0014009 | glial cell proliferation |
| GO:0060022 | hard palate development |
| GO:0002089 | lens morphogenesis in camera-type eye |
| GO:0060174 | limb bud formation |
| GO:0060425 | lung morphogenesis |
| GO:0060548 | negative regulation of cell death |
| GO:0060253 | negative regulation of glial cell proliferation |
| GO:0050672 | negative regulation of lymphocyte proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0014032 | neural crest cell development |
| GO:0001841 | neural tube formation |
| GO:0060563 | neuroepithelial cell differentiation |
| GO:0030182 | neuron differentiation |
| GO:0003357 | noradrenergic neuron differentiation |
| GO:0003151 | outflow tract morphogenesis |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0035332 | positive regulation of hippo signaling |
| GO:0046887 | positive regulation of hormone secretion |
| GO:2001111 | positive regulation of lens epithelial cell proliferation |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:2000648 | positive regulation of stem cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0072395 | signal transduction involved in cell cycle checkpoint |
| GO:0035914 | skeletal muscle cell differentiation |
| GO:0060023 | soft palate development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |
| GO:0048485 | sympathetic nervous system development |
| GO:0060412 | ventricular septum morphogenesis |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50118 | HMG_BOX_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00505 | HMG_box |