| Tag | Content |
|---|---|
| Uniprot ID | P0C1G9; O35178; O89036; Q04889; |
| Entrez ID | 84046 |
| Genbank protein ID | CAA06166.1 |
| Genbank nucleotide ID | NM_053349.1 |
| Ensembl protein ID | ENSRNOP00000040127 |
| Ensembl nucleotide ID | ENSRNOG00000030034 |
| Gene name | Transcription factor SOX-11 |
| Gene symbol | Sox11 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription factor that acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). |
| Sequence | MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 60 KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 120 RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCGAGK 180 AAKCVFLDDD DEEDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPAQQQPP QLLRRYSVAK 240 VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS 300 SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS 360 LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY 395 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOX11 | A0A452FZZ0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SOX11 | 6664 | P35716 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sox11 | 20666 | Q7M6Y2 | CPO,CLP | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SOX11 | 100608531 | A0A2I3TNT6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SOX11 | 100514639 | F1S9L1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Sox11 | 84046 | P0C1G9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0044798 | nuclear transcription factor complex |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0003211 | cardiac ventricle formation |
| GO:0030154 | cell differentiation |
| GO:0008283 | cell population proliferation |
| GO:0061386 | closure of optic fissure |
| GO:0061303 | cornea development in camera-type eye |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0021782 | glial cell development |
| GO:0014009 | glial cell proliferation |
| GO:0060022 | hard palate development |
| GO:0001822 | kidney development |
| GO:0002089 | lens morphogenesis in camera-type eye |
| GO:0060174 | limb bud formation |
| GO:0060425 | lung morphogenesis |
| GO:0060548 | negative regulation of cell death |
| GO:0010629 | negative regulation of gene expression |
| GO:0060253 | negative regulation of glial cell proliferation |
| GO:0050672 | negative regulation of lymphocyte proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| GO:0014032 | neural crest cell development |
| GO:0001841 | neural tube formation |
| GO:0060563 | neuroepithelial cell differentiation |
| GO:0030182 | neuron differentiation |
| GO:0003357 | noradrenergic neuron differentiation |
| GO:0014003 | oligodendrocyte development |
| GO:0003151 | outflow tract morphogenesis |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0035332 | positive regulation of hippo signaling |
| GO:0046887 | positive regulation of hormone secretion |
| GO:2001111 | positive regulation of lens epithelial cell proliferation |
| GO:0050769 | positive regulation of neurogenesis |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045778 | positive regulation of ossification |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:2000648 | positive regulation of stem cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0072395 | signal transduction involved in cell cycle checkpoint |
| GO:0035914 | skeletal muscle cell differentiation |
| GO:0001501 | skeletal system development |
| GO:0060023 | soft palate development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |
| GO:0048485 | sympathetic nervous system development |
| GO:0060412 | ventricular septum morphogenesis |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50118 | HMG_BOX_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00505 | HMG_box |