| Tag | Content |
|---|---|
| Uniprot ID | A0A452DRF6 |
| Entrez ID | 106501727 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018064404.1 |
| Ensembl protein ID | ENSCHIP00000002285 |
| Ensembl nucleotide ID | ENSCHIG00000004852 |
| Gene name | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 |
| Gene symbol | DPH1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. |
| Sequence | MAALVAAEAA DSCSRNGPGR GRAPRGRLAN QIPAEILNNP QLQAAIQVLP SNYNFEIPKT 60 IWRIQQAQAK KVALQMPEGL LLFACTIVDI LERFTEAEVM VMGDVTYGAC CVDDFTARAL 120 GADFLVHYGH SCLVPMDTSA QDFRVLYVFV DIRIDTAHLL DSIRLTFPPA SALALVSTIQ 180 FVSTLQAAAQ ELKAEYRVSV PQCKPLSPGE ILGCTSPCLP KEVEAVVYLG DGRFHLESVM 240 IANPNISAYR YDPYSKVLSR EHYDHQRMQA NRQEAIATAR SAKSWGLILG TLGRQGSPKI 300 LEHLESRLQA LGLPFVRLLL SEIFPSKLSL LPEVDVWVQV ACPRLSIDWG TAFPKPLLTP 360 YEAAVALRDI SWQQPYPMDF YASSSLGPWT VNHGRDRLLQ VPGRPGLEKV QGGPARPSPA 420 AACEACSCRG EEVSAIAP 438 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DPH1 | F1MGR8 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | DPH1 | 106501727 | A0A452DRF6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DPH1 | 1801 | Q9BZG8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dph1 | 116905 | Q5NCQ5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DPH1 | 454415 | H2QBU9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Dph1 | 287523 | B2RYK2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dph1 | F1QK18 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016740 | transferase activity |
| GO:0017183 | peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
| Pfam ID | Pfam Term |
|---|---|
| PF01866 | Diphthamide_syn |