| Tag | Content |
|---|---|
| Uniprot ID | A0A452ECE7 |
| Entrez ID | 102171973 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005683520.3 |
| Ensembl protein ID | ENSCHIP00000009629 |
| Ensembl nucleotide ID | ENSCHIG00000012433 |
| Gene name | BHLH domain-containing protein |
| Gene symbol | HAND2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM 60 ALSYSPEYAS GAASLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA 120 ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK 180 RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ 217 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAND2 | 102171973 | A0A452ECE7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HAND2 | 9464 | P61296 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hand2 | 15111 | Q61039 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | HAND2 | 741581 | H2R7W4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | HAND2 | A0A287BKC6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hand2 | A0A0G2K7Q4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | hand2 | 58150 | A2BDM6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000790 | nuclear chromatin |
| GO:0005667 | transcription factor complex |
| GO:0003680 | AT DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0070888 | E-box binding |
| GO:0042803 | protein homodimerization activity |
| GO:0008134 | transcription factor binding |
| GO:0007512 | adult heart development |
| GO:0003278 | apoptotic process involved in heart morphogenesis |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:0003219 | cardiac right ventricle formation |
| GO:0060536 | cartilage morphogenesis |
| GO:0061325 | cell proliferation involved in outflow tract morphogenesis |
| GO:0060982 | coronary artery morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:0010463 | mesenchymal cell proliferation |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| GO:0043392 | negative regulation of DNA binding |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0010629 | negative regulation of gene expression |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048935 | peripheral nervous system neuron development |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:1900745 | positive regulation of p38MAPK cascade |
| GO:2000764 | positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis |
| GO:2000763 | positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process |
| GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| GO:1903929 | primary palate development |
| GO:0003266 | regulation of secondary heart field cardioblast proliferation |
| GO:0034103 | regulation of tissue remodeling |
| GO:0001967 | suckling behavior |
| GO:0048485 | sympathetic nervous system development |
| GO:0048538 | thymus development |
| GO:0043586 | tongue development |
| GO:0061032 | visceral serous pericardium development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50888 | BHLH |
| Pfam ID | Pfam Term |
|---|---|
| PF00010 | HLH |