| Tag | Content |
|---|---|
| Uniprot ID | A7MB80 |
| Entrez ID | 534669 |
| Genbank protein ID | AAI51388.1 |
| Genbank nucleotide ID | NM_001102177.1 |
| Ensembl protein ID | ENSBTAP00000058347; ENSBTAP00000012904; |
| Ensembl nucleotide ID | ENSBTAG00000009780 |
| Gene name | General transcription factor II-I |
| Gene symbol | GTF2I |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity). |
| Sequence | MAQVAVSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 60 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTAQAN RMSVDAVEIE TLRKTVEDYF 120 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 180 SFIIKRPFLE PKKHLGGRVM VTDAERSMIS PSGSCGPVKV KTEPSEDSGI SLEMAAVTVK 240 EESEDPDYYQ YNIQAGPSET DDVDDKLPLS KSLQGSHHSS EGNEGTEMEV PAEDDDYPPP 300 AKRPKSSEPP QPPVTEPANA GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG 360 PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS 420 TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND 480 LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK 540 EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP 600 TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV 660 PEIEVTVEGP NNSNPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF 720 NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI 780 KFIIKKPEMF ETAIKESTSS SKSPPRKINS SPSVNTTASG VEDLNIIQVT IPDDDNERLS 840 KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 900 LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE GPVIQESAEP TQLEVPATEE 960 IKETDGNSQI KQEPDPTW 978 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GTF2I | 534669 | A7MB80 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GTF2I | 479714 | F6Y258 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GTF2I | 102190656 | A0A452DXC3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GTF2I | 2969 | P78347 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gtf2i | 14886 | Q9ESZ8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GTF2I | 100513345 | F1RJL2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Gtf2i | 353256 | A0A0G2K4T7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0006366 | transcription by RNA polymerase II |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51139 | GTF2I |
| Pfam ID | Pfam Term |
|---|---|
| PF02946 | GTF2I |