| Tag | Content |
|---|---|
| Uniprot ID | E1BHJ4 |
| Entrez ID | 540868 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192793.1 |
| Ensembl protein ID | ENSBTAP00000016198 |
| Ensembl nucleotide ID | ENSBTAG00000012212 |
| Gene name | Cytochrome P450 26B1 |
| Gene symbol | CYP26B1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity). |
| Sequence | MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP KGSMGFPLIG 60 ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE NVRKILMGEH HLVSTEWPRS 120 TRMLLGPNTV SNSIGDIHRN KRKVFSKIFS HEALESYLPK IQLVIQDTLR AWSSHPEAIN 180 VYQEAQKLTF RMAIRVLLGF SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR 240 QTLQKGLEKA IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300 TASASTSLIM QLLKHPAVLE KLREELRAKG LLHSGGCPCE GTLRLDTLSG LHYLDCVIKE 360 VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH DTAPVFKDVN VFDPDRFGQA 420 RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF LKVLAVELAS TSRFELATRT FPRITLVPVL 480 HPVDGLSVKF FGLDSNQNKI LPETEAMLSA TV 512 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP26B1 | 540868 | E1BHJ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 483120 | E2QSZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 102187233 | A0A452EY95 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 56603 | Q9NR63 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cyp26b1 | 232174 | Q811W2 | CPO | E11.75, E11.5, E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | CYP26B1 | 738157 | A0A2I3SUD0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 100521659 | F1SLE8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Cyp26b1 | 312495 | G3V7X8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cyp26b1 | 324188 | A0A0R4I9F4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0000249 | C-22 sterol desaturase activity |
| GO:0020037 | heme binding |
| GO:0005506 | iron ion binding |
| GO:0004497 | monooxygenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0008401 | retinoic acid 4-hydroxylase activity |
| GO:0001972 | retinoic acid binding |
| GO:0060349 | bone morphogenesis |
| GO:0001709 | cell fate determination |
| GO:0071300 | cellular response to retinoic acid |
| GO:0070268 | cornification |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0006696 | ergosterol biosynthetic process |
| GO:0061436 | establishment of skin barrier |
| GO:0001768 | establishment of T cell polarity |
| GO:0006954 | inflammatory response |
| GO:0007140 | male meiotic nuclear division |
| GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
| GO:0055114 | oxidation-reduction process |
| GO:0010628 | positive regulation of gene expression |
| GO:2001037 | positive regulation of tongue muscle cell differentiation |
| GO:0009954 | proximal/distal pattern formation |
| GO:0045580 | regulation of T cell differentiation |
| GO:0034653 | retinoic acid catabolic process |
| GO:0042573 | retinoic acid metabolic process |
| GO:0048384 | retinoic acid receptor signaling pathway |
| GO:0007283 | spermatogenesis |
| GO:0016125 | sterol metabolic process |
| GO:0043587 | tongue morphogenesis |
| GO:0006805 | xenobiotic metabolic process |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |