| Tag | Content |
|---|---|
| Uniprot ID | Q811W2; Q3TM12; |
| Entrez ID | 232174 |
| Genbank protein ID | AAH59246.1; AAN08613.1; EDK99117.1; BAE23242.1; BAE38630.1; |
| Genbank nucleotide ID | NM_001177713.1; NM_175475.3; |
| Ensembl protein ID | ENSMUSP00000145092; ENSMUSP00000076886; ENSMUSP00000128391; |
| Ensembl nucleotide ID | ENSMUSG00000063415 |
| Gene name | Cytochrome P450 26B1 |
| Gene symbol | Cyp26b1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E11.75, E11.5, E12.5, E13.5, E14.5 |
| Data sources | Manually collected |
| Reference | 19235731 |
| Functional description | Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation (By similarity). Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA (By similarity). Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA (By similarity). Essential for postnatal survival (PubMed:16461896, PubMed:16574820, PubMed:19838304). Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis (PubMed:16461896, PubMed:16574820, PubMed:19838304). Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry (PubMed:16461896, PubMed:16574820, PubMed:19838304). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272). |
| Sequence | MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP KGSMGFPLIG 60 ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE NVRKILLGEH QLVSTEWPRS 120 ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS HEALESYLPK IQLVIQDTLR AWSSQPEAIN 180 VYQEAQRLTF RMAVRVLLGF SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR 240 QILQKGLEKA IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300 TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS LRYLDCVIKE 360 VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH DTAPVFKDVN VFDPDRFSQA 420 RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF LKVLAVELAS TSRFELATRT FPRITLVPVL 480 HPVDGLSVKF FGLDSNQNEI LPETEAMLSA TV 512 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP26B1 | 540868 | E1BHJ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 483120 | E2QSZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 102187233 | A0A452EY95 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 56603 | Q9NR63 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cyp26b1 | 232174 | Q811W2 | CPO | E11.75, E11.5, E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | CYP26B1 | 738157 | A0A2I3SUD0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP26B1 | 100521659 | F1SLE8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Cyp26b1 | 312495 | G3V7X8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cyp26b1 | 324188 | A0A0R4I9F4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000249 | C-22 sterol desaturase activity | IBA |
| GO:0001972 | retinoic acid binding | ISO |
| GO:0004497 | monooxygenase activity | IBA |
| GO:0005506 | iron ion binding | IEA |
| GO:0008401 | retinoic acid 4-hydroxylase activity | ISO |
| GO:0016491 | oxidoreductase activity | IBA |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ISS |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ISO |
| GO:0020037 | heme binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001709 | cell fate determination | IMP |
| GO:0001768 | establishment of T cell polarity | IMP |
| GO:0001822 | kidney development | IEA |
| GO:0006696 | ergosterol biosynthetic process | IBA |
| GO:0006805 | xenobiotic metabolic process | ISS |
| GO:0006805 | xenobiotic metabolic process | ISO |
| GO:0006954 | inflammatory response | IMP |
| GO:0007140 | male meiotic nuclear division | IMP |
| GO:0007283 | spermatogenesis | IMP |
| GO:0009954 | proximal/distal pattern formation | IMP |
| GO:0010628 | positive regulation of gene expression | IMP |
| GO:0016125 | sterol metabolic process | IBA |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0033189 | response to vitamin A | IEA |
| GO:0034653 | retinoic acid catabolic process | ISO |
| GO:0034653 | retinoic acid catabolic process | IC |
| GO:0042573 | retinoic acid metabolic process | ISS |
| GO:0042573 | retinoic acid metabolic process | ISO |
| GO:0042573 | retinoic acid metabolic process | IC |
| GO:0043587 | tongue morphogenesis | IMP |
| GO:0045580 | regulation of T cell differentiation | IMP |
| GO:0048384 | retinoic acid receptor signaling pathway | IDA |
| GO:0048384 | retinoic acid receptor signaling pathway | IMP |
| GO:0048385 | regulation of retinoic acid receptor signaling pathway | IMP |
| GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | IMP |
| GO:0055114 | oxidation-reduction process | ISO |
| GO:0055114 | oxidation-reduction process | IBA |
| GO:0060349 | bone morphogenesis | ISO |
| GO:0061436 | establishment of skin barrier | IMP |
| GO:0070268 | cornification | IMP |
| GO:0071300 | cellular response to retinoic acid | IEP |
| GO:2001037 | positive regulation of tongue muscle cell differentiation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-211859 | Biological oxidations | IEA |
| R-MMU-211897 | Cytochrome P450 - arranged by substrate type | IEA |
| R-MMU-211916 | Vitamins | IEA |
| R-MMU-211945 | Phase I - Functionalization of compounds | IEA |
| R-MMU-5362517 | Signaling by Retinoic Acid | IEA |
| R-MMU-5365859 | RA biosynthesis pathway | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |