Gene: MSC

Basic information

Tag Content
Uniprot ID E2R7N0
Entrez ID 486992
Genbank protein ID
Genbank nucleotide ID XM_544121.3
Ensembl protein ID ENSCAFP00000011719
Ensembl nucleotide ID ENSCAFG00000007923
Gene name Musculin
Gene symbol MSC
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSTGSVSDPE EMELRGLQRG YPAPAPKRPP LRGAEGSYIS PSDNSSAEEE DPEGEEERCA 60
LGAAGGAEGC RRKRPRVAGG GGGKKPLPPK GSAADCKQSQ RNAANARERA RMRVLSKAFS 120
RLKTSLPWVP PDTKLSKLDT LRLASSYIAH LRQLLQEDRY ENGYVHPVNL TWPFVVSGRP 180
DSDTKEVSAA NRLCGTTA 198

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMSC507407G3X7V5Bos taurusPredictionMore>>
1:1 orthologMSC486992E2R7N0Canis lupus familiarisPredictionMore>>
1:1 orthologMSC108637528A0A452EHD7Capra hircusPredictionMore>>
1:1 orthologMSC9242O60682Homo sapiensPredictionMore>>
1:1 orthologMsc17681O88940CPOMus musculusPublicationMore>>
1:1 orthologMSCH2R068Pan troglodytesPredictionMore>>
1:1 orthologMSC100155518F1RWI0Sus scrofaPredictionMore>>
1:1 orthologMSC100338807G1SSJ5Oryctolagus cuniculusPredictionMore>>
1:1 orthologMsc312897D3ZWP1Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0046983 protein dimerization activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0014707 branchiomeric skeletal muscle development
GO:1990830 cellular response to leukemia inhibitory factor
GO:0060539 diaphragm development
GO:0006357 regulation of transcription by RNA polymerase II
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS50888 BHLH

Pfam

Pfam ID Pfam Term
PF00010 HLH