| Tag | Content |
|---|---|
| Uniprot ID | F2Z4J0 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSBTAP00000000139 |
| Ensembl nucleotide ID | ENSBTAG00000000128 |
| Gene name | Fibroblast growth factor |
| Gene symbol | FGF18 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 60 TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 120 DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 180 GQAELQKPFK YTTVTKRSRR IRPTHPG 207 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF18 | F2Z4J0 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | FGF18 | A0A452E8D6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FGF18 | 8817 | O76093 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgf18 | 14172 | O89101 | CPO | E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF18 | H2R563 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | FGF18 | 100525013 | A0A5G2QUY7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Fgf18 | M0R6D5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fgf18a | F1QKX4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0005730 | nucleolus |
| GO:0008083 | growth factor activity |
| GO:0005105 | type 1 fibroblast growth factor receptor binding |
| GO:0005111 | type 2 fibroblast growth factor receptor binding |
| GO:0001525 | angiogenesis |
| GO:0002063 | chondrocyte development |
| GO:0001958 | endochondral ossification |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0001957 | intramembranous ossification |
| GO:0030324 | lung development |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |