Gene: Fgf18

Basic information

Tag Content
Uniprot ID O89101
Entrez ID 14172
Genbank protein ID AAF22976.1; AAC62239.1; BAA31980.1;
Genbank nucleotide ID NM_008005.2
Ensembl protein ID ENSMUSP00000020507
Ensembl nucleotide ID ENSMUSG00000057967
Gene name Fibroblast growth factor 18
Gene symbol Fgf18
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E16.5
Data sources Manually collected
Reference 11937493
Functional description Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).
Sequence
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 60
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 120
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 180
GQAELQKPFK YTTVTKRSRR IRPTHPG 207

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF18F2Z4J0Bos taurusPredictionMore>>
1:1 orthologFGF18A0A452E8D6Capra hircusPredictionMore>>
1:1 orthologFGF188817O76093Homo sapiensPublicationMore>>
1:1 orthologFgf1814172O89101CPOE16.5Mus musculusPublicationMore>>
1:1 orthologFGF18H2R563Pan troglodytesPredictionMore>>
1:1 orthologFGF18100525013A0A5G2QUY7Sus scrofaPredictionMore>>
1:1 orthologFgf18M0R6D5Rattus norvegicusPredictionMore>>
1:1 orthologfgf18aF1QKX4Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
FGF18rs4043716Genotyping; TDT19727229

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005104 fibroblast growth factor receptor bindingTAS
GO:0005105 type 1 fibroblast growth factor receptor bindingISO
GO:0005111 type 2 fibroblast growth factor receptor bindingISO
GO:0008083 growth factor activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001503 ossificationIMP
GO:0001525 angiogenesisIMP
GO:0001957 intramembranous ossificationIMP
GO:0001958 endochondral ossificationIMP
GO:0002063 chondrocyte developmentIMP
GO:0007165 signal transductionTAS
GO:0007399 nervous system developmentISO
GO:0008283 cell population proliferationISO
GO:0008284 positive regulation of cell population proliferationIMP
GO:0008543 fibroblast growth factor receptor signaling pathwayIGI
GO:0030324 lung developmentIMP
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathwayIMP
GO:0032332 positive regulation of chondrocyte differentiationIGI
GO:0043406 positive regulation of MAP kinase activityISO
GO:0043536 positive regulation of blood vessel endothelial cell migrationISO
GO:0045766 positive regulation of angiogenesisISO
GO:0070374 positive regulation of ERK1 and ERK2 cascadeIDA
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factorISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionIEA
GO:0005634 nucleusISO
GO:0005730 nucleolusISO
GO:0005737 cytoplasmISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-109704 PI3K CascadeIEA
R-MMU-112399 IRS-mediated signallingIEA
R-MMU-1257604 PIP3 activates AKT signalingIEA
R-MMU-1280215 Cytokine Signaling in Immune systemIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-168256 Immune SystemIEA
R-MMU-190236 Signaling by FGFRIEA
R-MMU-190239 FGFR3 ligand binding and activationIEA
R-MMU-190241 FGFR2 ligand binding and activationIEA
R-MMU-190322 FGFR4 ligand binding and activationIEA
R-MMU-190371 FGFR3b ligand binding and activationIEA
R-MMU-190372 FGFR3c ligand binding and activationIEA
R-MMU-190375 FGFR2c ligand binding and activationIEA
R-MMU-199418 Negative regulation of the PI3K/AKT networkIEA
R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-MMU-2428924 IGF1R signaling cascadeIEA
R-MMU-2428928 IRS-related events triggered by IGF1RIEA
R-MMU-5654221 Phospholipase C-mediated cascade; FGFR2IEA
R-MMU-5654227 Phospholipase C-mediated cascade; FGFR3IEA
R-MMU-5654228 Phospholipase C-mediated cascade; FGFR4IEA
R-MMU-5654695 PI-3K cascade:FGFR2IEA
R-MMU-5654696 Downstream signaling of activated FGFR2IEA
R-MMU-5654699 SHC-mediated cascade:FGFR2IEA
R-MMU-5654700 FRS-mediated FGFR2 signalingIEA
R-MMU-5654704 SHC-mediated cascade:FGFR3IEA
R-MMU-5654706 FRS-mediated FGFR3 signalingIEA
R-MMU-5654708 Downstream signaling of activated FGFR3IEA
R-MMU-5654710 PI-3K cascade:FGFR3IEA
R-MMU-5654712 FRS-mediated FGFR4 signalingIEA
R-MMU-5654716 Downstream signaling of activated FGFR4IEA
R-MMU-5654719 SHC-mediated cascade:FGFR4IEA
R-MMU-5654720 PI-3K cascade:FGFR4IEA
R-MMU-5654727 Negative regulation of FGFR2 signalingIEA
R-MMU-5654732 Negative regulation of FGFR3 signalingIEA
R-MMU-5654733 Negative regulation of FGFR4 signalingIEA
R-MMU-5654736 Signaling by FGFR1IEA
R-MMU-5654738 Signaling by FGFR2IEA
R-MMU-5654741 Signaling by FGFR3IEA
R-MMU-5654743 Signaling by FGFR4IEA
R-MMU-5658623 FGFRL1 modulation of FGFR1 signalingIEA
R-MMU-5673001 RAF/MAP kinase cascadeIEA
R-MMU-5683057 MAPK family signaling cascadesIEA
R-MMU-5684996 MAPK1/MAPK3 signalingIEA
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingIEA
R-MMU-74751 Insulin receptor signalling cascadeIEA
R-MMU-74752 Signaling by Insulin receptorIEA
R-MMU-9006925 Intracellular signaling by second messengersIEA
R-MMU-9006934 Signaling by Receptor Tyrosine KinasesIEA
R-MMU-9607240 FLT3 SignalingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR028289 FGF18
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF

Protein-miRNA interaction