| Tag | Content |
|---|---|
| Uniprot ID | H2QDR6; A0A2J8KC49; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000016293 |
| Ensembl nucleotide ID | ENSPTRG00000009592 |
| Gene name | Transcription factor SOX-9 |
| Gene symbol | SOX9 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE NTFPKGEPDL 60 KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR 120 RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK 180 SVKNGQAEAE EATEQTHISP NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT 240 PKTDVQPGKA DLKREGRPLP EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP 300 NGHPGVPATH GQVTYTGSYG ISSTAATPAS AGHVWMSKQQ APPPPPQQPP QAPPAPQAPP 360 QPQAAPPQQP AAPPQQPQAH TLTTLSSEPG QSQRTHIKTE QLSPSHYSEQ QQHSPQQIAY 420 SPFNLPHYSP SYPPITRSQY DYTDHQNSSS YYSHAAGQGT GLYSTFTYMN PAQRPMYTPI 480 ADTSGVPSIP QTHSPQHWEQ PVYTQLTRP 509 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOX9 | 106503295 | A0A452FKA9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOX9 | 6662 | P48436 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Sox9 | 20682 | Q04887 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SOX9 | H2QDR6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SOX9 | 396840 | F1RV30 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Sox9 | 140586 | F1LYL9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sox9a | 60641 | Q9DFH2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0044798 | nuclear transcription factor complex |
| GO:0005654 | nucleoplasm |
| GO:0008013 | beta-catenin binding |
| GO:0003682 | chromatin binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0097157 | pre-mRNA intronic binding |
| GO:0034236 | protein kinase A catalytic subunit binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0097065 | anterior head development |
| GO:0003180 | aortic valve morphogenesis |
| GO:0060018 | astrocyte fate commitment |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0060532 | bronchus cartilage development |
| GO:0019933 | cAMP-mediated signaling |
| GO:0001502 | cartilage condensation |
| GO:0001708 | cell fate specification |
| GO:0098609 | cell-cell adhesion |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0071504 | cellular response to heparin |
| GO:0071347 | cellular response to interleukin-1 |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0071300 | cellular response to retinoic acid |
| GO:0071560 | cellular response to transforming growth factor beta stimulus |
| GO:0007417 | central nervous system development |
| GO:0002062 | chondrocyte differentiation |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0003415 | chondrocyte hypertrophy |
| GO:0006338 | chromatin remodeling |
| GO:0090103 | cochlea morphogenesis |
| GO:0007010 | cytoskeleton organization |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0031018 | endocrine pancreas development |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0060517 | epithelial cell proliferation involved in prostatic bud elongation |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0030198 | extracellular matrix organization |
| GO:0001942 | hair follicle development |
| GO:0070384 | Harderian gland development |
| GO:0007507 | heart development |
| GO:0003188 | heart valve formation |
| GO:0060729 | intestinal epithelial structure maintenance |
| GO:0035622 | intrahepatic bile duct development |
| GO:0032808 | lacrimal gland development |
| GO:0060174 | limb bud formation |
| GO:0060487 | lung epithelial cell differentiation |
| GO:0061145 | lung smooth muscle development |
| GO:0019100 | male germ-line sex determination |
| GO:0030879 | mammary gland development |
| GO:0072289 | metanephric nephron tubule formation |
| GO:0002009 | morphogenesis of an epithelium |
| GO:0030502 | negative regulation of bone mineralization |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0030857 | negative regulation of epithelial cell differentiation |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0002683 | negative regulation of immune system process |
| GO:2001054 | negative regulation of mesenchymal cell apoptotic process |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0046533 | negative regulation of photoreceptor cell differentiation |
| GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0014032 | neural crest cell development |
| GO:0007219 | Notch signaling pathway |
| GO:0030903 | notochord development |
| GO:0006334 | nucleosome assembly |
| GO:0048709 | oligodendrocyte differentiation |
| GO:0001503 | ossification |
| GO:0030916 | otic vesicle formation |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:1902732 | positive regulation of chondrocyte proliferation |
| GO:0030858 | positive regulation of epithelial cell differentiation |
| GO:0010634 | positive regulation of epithelial cell migration |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:1901203 | positive regulation of extracellular matrix assembly |
| GO:2000020 | positive regulation of male gonad development |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:2000741 | positive regulation of mesenchymal stem cell differentiation |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0045732 | positive regulation of protein catabolic process |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0043491 | protein kinase B signaling |
| GO:0034504 | protein localization to nucleus |
| GO:0061046 | regulation of branching involved in lung morphogenesis |
| GO:0030155 | regulation of cell adhesion |
| GO:0010564 | regulation of cell cycle process |
| GO:0060784 | regulation of cell proliferation involved in tissue homeostasis |
| GO:2000794 | regulation of epithelial cell proliferation involved in lung morphogenesis |
| GO:0072034 | renal vesicle induction |
| GO:0060221 | retinal rod cell differentiation |
| GO:0060009 | Sertoli cell development |
| GO:0035019 | somatic stem cell population maintenance |
| GO:0007283 | spermatogenesis |
| GO:0060534 | trachea cartilage development |
| GO:0072197 | ureter morphogenesis |
| GO:0072193 | ureter smooth muscle cell differentiation |
| GO:0072190 | ureter urothelium development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50118 | HMG_BOX_2 |