| Tag | Content |
|---|---|
| Uniprot ID | H2R5G5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000048124 |
| Ensembl nucleotide ID | ENSPTRG00000018960 |
| Gene name | Twist-related protein 1 |
| Gene symbol | TWIST1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQDVSSSPVS PADDSLSNSE EEPDRQQPPS GKRGGRKRRS SGDEPGSPAQ GKRGKNGGGS 60 PQSYEELQTQ RVMANVRERQ RTQSLNEAFA ALRKIIPTLP SDKLSKIQTL KLAARYIDFL 120 YQVLQSDELD SKMASCSYVA HERLSYAFSV WRMEGAWSMS ASH 163 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TWIST1 | 782170 | G3N341 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TWIST1 | A0A452EBT3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TWIST1 | 7291 | Q15672 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Twist1 | 22160 | P26687 | CPO | E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TWIST1 | H2R5G5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 100516456 | A0A4X1TEI0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Twist1 | 85489 | Q9EPJ1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0070888 | E-box binding |
| GO:0019904 | protein domain specific binding |
| GO:0042803 | protein homodimerization activity |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0003180 | aortic valve morphogenesis |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:2000793 | cell proliferation involved in heart valve development |
| GO:0071456 | cellular response to hypoxia |
| GO:0060363 | cranial suture morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0003183 | mitral valve morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0035067 | negative regulation of histone acetylation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:2000276 | negative regulation of oxidative phosphorylation uncoupler activity |
| GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway |
| GO:0048642 | negative regulation of skeletal muscle tissue development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0001843 | neural tube closure |
| GO:0001764 | neuron migration |
| GO:0001649 | osteoblast differentiation |
| GO:2000147 | positive regulation of cell motility |
| GO:2000802 | positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50888 | BHLH |
| Pfam ID | Pfam Term |
|---|---|
| PF00010 | HLH |