CleftGeneDB-Search

Gene: Twist1

Basic information

Tag	Content
Uniprot ID	Q9EPJ1
Entrez ID	85489
Genbank protein ID	CAC20861.1; AAI66412.1;
Genbank nucleotide ID	NM_053530.2
Ensembl protein ID	ENSRNOP00000014763
Ensembl nucleotide ID	ENSRNOG00000011101
Gene name	Twist family bHLH transcription factor 1
Gene symbol	Twist1
Organism	Rattus norvegicus
NCBI taxa ID	10116
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MMQDVSSSPV SPADDSLSNS EEEPDRQQPA SGKRGARKRR SSRRSAGGSA GPGGATGGGI 60 GGGDEPGSPA QGKRGKKSAG GGGGAGGGGG GGGSSSGGGS PQSYEELQTQ RVMANVRERQ 120 RTQSLNEAFA ALRKIIPTLP SDKLSKIQTL KLAARYIDFL YQVLQSDELD SKMASCSYVA 180 HERLSYAFSV WRMEGAWSMS ASH 203

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

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Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	Twist1	22160	P26687	CPO	E13.5, E14.5, E15.5, E16.5	Mus musculus	Publication	More>>
1:1 ortholog		100516456	A0A4X1TEI0			Sus scrofa	Prediction	More>>
1:1 ortholog	TWIST1	782170	G3N341			Bos taurus	Prediction	More>>
1:1 ortholog	TWIST1		A0A452EBT3			Capra hircus	Prediction	More>>
1:1 ortholog	TWIST1	7291	Q15672			Homo sapiens	Prediction	More>>
1:1 ortholog	TWIST1		H2R5G5			Pan troglodytes	Prediction	More>>
1:1 ortholog	Twist1	85489	Q9EPJ1			Rattus norvegicus	Prediction	More>>

Showing 1 to 7 of 7 entries

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Gene ontology

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GO ID	GO Term
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0003180	aortic valve morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003700	DNA-binding transcription factor activity
GO:0005634	nucleus
GO:0006357	regulation of transcription by RNA polymerase II
GO:0008134	transcription factor binding
GO:0010628	positive regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0019904	protein domain specific binding