| Tag | Content |
|---|---|
| Uniprot ID | O08543; O08544; |
| Entrez ID | 13640 |
| Genbank protein ID | AAH40218.1; AAB50239.1; AAB50240.1; |
| Genbank nucleotide ID | NM_207654.2; NM_010109.3; |
| Ensembl protein ID | ENSMUSP00000076115; ENSMUSP00000077883; |
| Ensembl nucleotide ID | ENSMUSG00000048915 |
| Gene name | Ephrin-A5 |
| Gene symbol | Efna5 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 9491985 |
| Functional description | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. |
| Sequence | MLHVEMLTLL FLVLWMCVFS QDPGSKVVAD RYAVYWNSSN PRFQRGDYHI DVCINDYLDV 60 FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW ECNRPHSPNG PLKFSEKFQL 120 FTPFSLGFEF RPGREYFYIS SAIPDNGRRS CLKLKVFVRP TNSCMKTIGV HDRVFDVNDK 180 VENSLEPADD TVHESAEPSR GENAAQTPRI PSRLLAILLF LLAMLLTL 228 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EFNA5 | A0A452EE67 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EFNA5 | 1946 | P52803 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Efna5 | 13640 | O08543 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EFNA5 | 471594 | A0A2I3SW52 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EFNA5 | A0A287AHP3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Efna5 | G3V989 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005169 | neurotrophin TRKB receptor binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0045499 | chemorepellent activity | IDA |
| GO:0046875 | ephrin receptor binding | ISO |
| GO:0046875 | ephrin receptor binding | IPI |
| GO:0046875 | ephrin receptor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | IBA |
| GO:0007411 | axon guidance | IDA |
| GO:0007420 | brain development | ISO |
| GO:0022407 | regulation of cell-cell adhesion | ISO |
| GO:0022407 | regulation of cell-cell adhesion | IDA |
| GO:0022407 | regulation of cell-cell adhesion | IBA |
| GO:0022604 | regulation of cell morphogenesis | ISO |
| GO:0031290 | retinal ganglion cell axon guidance | IDA |
| GO:0032956 | regulation of actin cytoskeleton organization | ISO |
| GO:0032956 | regulation of actin cytoskeleton organization | IDA |
| GO:0032956 | regulation of actin cytoskeleton organization | IBA |
| GO:0043087 | regulation of GTPase activity | ISS |
| GO:0043087 | regulation of GTPase activity | ISO |
| GO:0043087 | regulation of GTPase activity | IDA |
| GO:0048013 | ephrin receptor signaling pathway | ISO |
| GO:0048013 | ephrin receptor signaling pathway | IDA |
| GO:0048013 | ephrin receptor signaling pathway | IBA |
| GO:0048668 | collateral sprouting | IDA |
| GO:0048672 | positive regulation of collateral sprouting | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | IDA |
| GO:0050919 | negative chemotaxis | IEA |
| GO:0051893 | regulation of focal adhesion assembly | ISS |
| GO:0051893 | regulation of focal adhesion assembly | ISO |
| GO:0051965 | positive regulation of synapse assembly | IDA |
| GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | IMP |
| GO:0070507 | regulation of microtubule cytoskeleton organization | ISS |
| GO:0070507 | regulation of microtubule cytoskeleton organization | ISO |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus | IDA |
| GO:0099560 | synaptic membrane adhesion | IDA |
| GO:0099560 | synaptic membrane adhesion | IMP |
| GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1904322 | cellular response to forskolin | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005604 | basement membrane | IDA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | IBA |
| GO:0005901 | caveola | IEA |
| GO:0005912 | adherens junction | IDA |
| GO:0031362 | anchored component of external side of plasma membrane | ISS |
| GO:0031362 | anchored component of external side of plasma membrane | ISO |
| GO:0071944 | cell periphery | IDA |
| GO:0098982 | GABA-ergic synapse | IDA |
| GO:0098982 | GABA-ergic synapse | IMP |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-2682334 | EPH-Ephrin signaling | IEA |
| R-MMU-3928663 | EPHA-mediated growth cone collapse | IEA |
| R-MMU-3928665 | EPH-ephrin mediated repulsion of cells | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0336 | GPI-anchor |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0524 | Neurogenesis |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| Pfam ID | Pfam Term |
|---|---|
| PF00812 | Ephrin |