Gene: Foxe1

Basic information

Tag Content
Uniprot ID O08771
Entrez ID 192274
Genbank protein ID EDL98835.1; CAA72174.1;
Genbank nucleotide ID NM_138909.1
Ensembl protein ID ENSRNOP00000012637
Ensembl nucleotide ID ENSRNOG00000023497
Gene name Forkhead box E1
Gene symbol Foxe1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTAESAPPPP PQPEALAAVK EERGEAAAGA GVPAEVAGRG AGGRRRKRPL QRGKPPYSYI 60
ALIAMAIAHA PERRLTLGGI YKFITERFPF YRDNPKKWQN SIRHNLTLND CFLKIPREAG 120
RPGKGNYWAL DPNAEDMFES GSFLRRRKRF KRSDLSTYPA YMHDAAAAAA AAAAAIFPGA 180
VPAARPAYPG AVYAGYAPPL AAPPPVYYPA ASPGPCRVFG LVPERPLSPD LGPAPSAAGG 240
SCAFAAAAGA PGTGSFQPAV CTGARPVNPA AYAAAYAGPD GAYPQGASSA LFAAAAGRLA 300
GPTSPTAGGG SGGVEATVDF YGRTSPGQFG AALGPCYNPS GQLGAGGGGA YHSRHATAYP 360
GAVDRFVSAM

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFOXE1616734F1ME54Bos taurusPredictionMore>>
1:1 orthologFOXE1106502413A0A452DS04Capra hircusPredictionMore>>
1:1 orthologFOXE12304O00358CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologFoxe1110805Q8R2I0CPOMus musculusPublicationMore>>
1:1 orthologFOXE1100610790H2R467Pan troglodytesPredictionMore>>
1:1 orthologFOXE1100157892F1SSG9Sus scrofaPredictionMore>>
1:1 orthologFoxe1192274O08771Rattus norvegicusPredictionMore>>
1:1 orthologfoxe1R4GEW1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0043565 sequence-specific DNA binding
GO:0009653 anatomical structure morphogenesis
GO:0030154 cell differentiation
GO:0016477 cell migration
GO:1904888 cranial skeletal system development
GO:0048562 embryonic organ morphogenesis
GO:0031069 hair follicle morphogenesis
GO:0060022 hard palate development
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0060465 pharynx development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006355 regulation of transcription, DNA-templated
GO:0060021 roof of mouth development
GO:0060023 soft palate development
GO:0048538 thymus development
GO:0030878 thyroid gland development
GO:0006590 thyroid hormone generation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS00657 FORK_HEAD_1
PS00658 FORK_HEAD_2
PS50039 FORK_HEAD_3

Pfam

Pfam ID Pfam Term
PF00250 Forkhead