Gene: Tgfb1

Basic information

Tag Content
Uniprot ID P17246; Q53YM8;
Entrez ID 59086
Genbank protein ID CAA36741.1; AAS55640.1; AAH76380.1;
Genbank nucleotide ID NM_021578.2
Ensembl protein ID ENSRNOP00000028051
Ensembl nucleotide ID ENSRNOG00000020652
Gene name Transforming growth factor beta-1 proprotein
Gene symbol Tgfb1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Sequence
MPPSGLRLLP LLLPLPWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA 60
SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESADPEPEPE ADYYAKEVTR VLMVDRNNAI 120
YDKTKDITHS IYMFFNTSDI REAVPEPPLL SRAELRLQRF KSTVEQHVEL YQKYSNNSWR 180
YLGNRLLTPT DTPEWLSFDV TGVVRQWLNQ GDGIQGFRFS AHCSCDSKDN VLHVEINGIS 240
PKRRGDLGTI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI 300
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA 360
LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTGFB1F1PI70Canis lupus familiarisPredictionMore>>
1:1 orthologTGF beta102191364G9LQW0Capra hircusPredictionMore>>
1:1 orthologTGFB1100033900O19011Equus caballusPredictionMore>>
1:1 orthologTGFB17040P01137Homo sapiensPublicationMore>>
1:1 orthologTgfb121803P04202CPOE12.5, E14.0, E13.5, E15.0, E14.5, E15.5, E17.5Mus musculusPublicationMore>>
1:1 orthologTGFB1456060H2QGE0Pan troglodytesPredictionMore>>
1:1 orthologTGFB1397078P07200Sus scrofaPredictionMore>>
1:1 orthologTgfb159086P17246Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030424 axon
GO:0072562 blood microparticle
GO:0005623 cell
GO:0009986 cell surface
GO:0062023 collagen-containing extracellular matrix
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0005615 extracellular space
GO:0043025 neuronal cell body
GO:0005634 nucleus
GO:0030141 secretory granule
GO:0003823 antigen binding
GO:0005125 cytokine activity
GO:0019899 enzyme binding
GO:0008083 growth factor activity
GO:0042802 identical protein binding
GO:0047485 protein N-terminus binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0044877 protein-containing complex binding
GO:0005160 transforming growth factor beta receptor binding
GO:0034713 type I transforming growth factor beta receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0007568 aging
GO:0031100 animal organ regeneration
GO:0003180 aortic valve morphogenesis
GO:0006754 ATP biosynthetic process
GO:0030509 BMP signaling pathway
GO:0060751 branch elongation involved in mammary gland duct branching
GO:0001775 cell activation
GO:0007050 cell cycle arrest
GO:0016477 cell migration
GO:0008283 cell population proliferation
GO:0045216 cell-cell junction organization
GO:0006874 cellular calcium ion homeostasis
GO:0071549 cellular response to dexamethasone stimulus
GO:0071363 cellular response to growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:0071479 cellular response to ionizing radiation
GO:0071260 cellular response to mechanical stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0002062 chondrocyte differentiation
GO:0007182 common-partner SMAD protein phosphorylation
GO:0061448 connective tissue development
GO:0009817 defense response to fungus, incompatible interaction
GO:0048565 digestive tract development
GO:1990402 embryonic liver development
GO:0007492 endoderm development
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0001837 epithelial to mesenchymal transition
GO:0085029 extracellular matrix assembly
GO:0097191 extrinsic apoptotic signaling pathway
GO:0060325 face morphogenesis
GO:0007565 female pregnancy
GO:0060364 frontal suture morphogenesis
GO:0008354 germ cell migration
GO:0007507 heart development
GO:0003179 heart valve morphogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0030214 hyaluronan catabolic process
GO:0006954 inflammatory response
GO:0048839 inner ear development
GO:0070306 lens fiber cell differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0097421 liver regeneration
GO:0030324 lung development
GO:0048535 lymph node development
GO:0060744 mammary gland branching involved in thelarche
GO:0030879 mammary gland development
GO:0000165 MAPK cascade
GO:0031293 membrane protein intracellular domain proteolysis
GO:0007093 mitotic cell cycle checkpoint
GO:0032943 mononuclear cell proliferation
GO:0001763 morphogenesis of a branching structure
GO:0046716 muscle cell cellular homeostasis
GO:0042552 myelination
GO:0043011 myeloid dendritic cell differentiation
GO:0070168 negative regulation of biomineral tissue development
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045786 negative regulation of cell cycle
GO:0045596 negative regulation of cell differentiation
GO:0030308 negative regulation of cell growth
GO:0008285 negative regulation of cell population proliferation
GO:0022408 negative regulation of cell-cell adhesion
GO:0045918 negative regulation of cytolysis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0045599 negative regulation of fat cell differentiation
GO:0010629 negative regulation of gene expression
GO:0060965 negative regulation of gene silencing by miRNA
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:0050777 negative regulation of immune response
GO:0032700 negative regulation of interleukin-17 production
GO:0010936 negative regulation of macrophage cytokine production
GO:0045930 negative regulation of mitotic cell cycle
GO:0045662 negative regulation of myoblast differentiation
GO:0007406 negative regulation of neuroblast proliferation
GO:0030279 negative regulation of ossification
GO:0050765 negative regulation of phagocytosis
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903077 negative regulation of protein localization to plasma membrane
GO:0001933 negative regulation of protein phosphorylation
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0050868 negative regulation of T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of transcription, DNA-templated
GO:0001843 neural tube closure
GO:0021915 neural tube development
GO:0007219 Notch signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0014003 oligodendrocyte development
GO:0043932 ossification involved in bone remodeling
GO:0030316 osteoclast differentiation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0006796 phosphate-containing compound metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0030501 positive regulation of bone mineralization
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:0071158 positive regulation of cell cycle arrest
GO:0051781 positive regulation of cell division
GO:0030335 positive regulation of cell migration
GO:0008284 positive regulation of cell population proliferation
GO:0032270 positive regulation of cellular protein metabolic process
GO:0050921 positive regulation of chemotaxis
GO:0032967 positive regulation of collagen biosynthetic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0031536 positive regulation of exit from mitosis
GO:0010763 positive regulation of fibroblast migration
GO:0048146 positive regulation of fibroblast proliferation
GO:0010628 positive regulation of gene expression
GO:0035066 positive regulation of histone acetylation
GO:0031065 positive regulation of histone deacetylation
GO:0032740 positive regulation of interleukin-17 production
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0043406 positive regulation of MAP kinase activity
GO:0014008 positive regulation of microglia differentiation
GO:0071677 positive regulation of mononuclear cell migration
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0042482 positive regulation of odontogenesis
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:0035307 positive regulation of protein dephosphorylation
GO:0042307 positive regulation of protein import into nucleus
GO:0051897 positive regulation of protein kinase B signaling
GO:1900182 positive regulation of protein localization to nucleus
GO:0001934 positive regulation of protein phosphorylation
GO:0050714 positive regulation of protein secretion
GO:0031334 positive regulation of protein-containing complex assembly
GO:1903911 positive regulation of receptor clustering
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0032930 positive regulation of superoxide anion generation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0043117 positive regulation of vascular permeability
GO:0006611 protein export from nucleus
GO:0043491 protein kinase B signaling
GO:0006468 protein phosphorylation
GO:0032801 receptor catabolic process
GO:2000249 regulation of actin cytoskeleton reorganization
GO:0051098 regulation of binding
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 regulation of cartilage development
GO:0001558 regulation of cell growth
GO:0042127 regulation of cell population proliferation
GO:0051101 regulation of DNA binding
GO:0010468 regulation of gene expression
GO:0032667 regulation of interleukin-23 production
GO:0042306 regulation of protein import into nucleus
GO:0045589 regulation of regulatory T cell differentiation
GO:0060390 regulation of SMAD protein signal transduction
GO:0002028 regulation of sodium ion transport
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0045066 regulatory T cell differentiation
GO:0070723 response to cholesterol
GO:0042493 response to drug
GO:0032355 response to estradiol
GO:0009749 response to glucose
GO:0001666 response to hypoxia
GO:0035902 response to immobilization stress
GO:0034616 response to laminar fluid shear stress
GO:0014070 response to organic cyclic compound
GO:0010033 response to organic substance
GO:0032570 response to progesterone
GO:0009314 response to radiation
GO:1902074 response to salt
GO:0033280 response to vitamin D
GO:0009611 response to wounding
GO:0007435 salivary gland morphogenesis
GO:0007183 SMAD protein complex assembly
GO:0060395 SMAD protein signal transduction
GO:0042110 T cell activation
GO:0030217 T cell differentiation
GO:0043029 T cell homeostasis
GO:0002513 tolerance induction to self antigen
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development
GO:0001657 ureteric bud development
GO:0001570 vasculogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0042060 wound healing

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0165 Cleavage on pair of basic residues
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-0497 Mitogen
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR003939 TGFb1
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide