| Tag | Content |
|---|---|
| Uniprot ID | P17246; Q53YM8; |
| Entrez ID | 59086 |
| Genbank protein ID | CAA36741.1; AAS55640.1; AAH76380.1; |
| Genbank nucleotide ID | NM_021578.2 |
| Ensembl protein ID | ENSRNOP00000028051 |
| Ensembl nucleotide ID | ENSRNOG00000020652 |
| Gene name | Transforming growth factor beta-1 proprotein |
| Gene symbol | Tgfb1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Sequence | MPPSGLRLLP LLLPLPWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA 60 SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESADPEPEPE ADYYAKEVTR VLMVDRNNAI 120 YDKTKDITHS IYMFFNTSDI REAVPEPPLL SRAELRLQRF KSTVEQHVEL YQKYSNNSWR 180 YLGNRLLTPT DTPEWLSFDV TGVVRQWLNQ GDGIQGFRFS AHCSCDSKDN VLHVEINGIS 240 PKRRGDLGTI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI 300 DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA 360 LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB1 | F1PI70 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TGF beta | 102191364 | G9LQW0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB1 | 100033900 | O19011 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TGFB1 | 7040 | P01137 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tgfb1 | 21803 | P04202 | CPO | E12.5, E14.0, E13.5, E15.0, E14.5, E15.5, E17.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFB1 | 456060 | H2QGE0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFB1 | 397078 | P07200 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tgfb1 | 59086 | P17246 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0072562 | blood microparticle |
| GO:0005623 | cell |
| GO:0009986 | cell surface |
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005737 | cytoplasm |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0043025 | neuronal cell body |
| GO:0005634 | nucleus |
| GO:0030141 | secretory granule |
| GO:0003823 | antigen binding |
| GO:0005125 | cytokine activity |
| GO:0019899 | enzyme binding |
| GO:0008083 | growth factor activity |
| GO:0042802 | identical protein binding |
| GO:0047485 | protein N-terminus binding |
| GO:0043539 | protein serine/threonine kinase activator activity |
| GO:0044877 | protein-containing complex binding |
| GO:0005160 | transforming growth factor beta receptor binding |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| GO:0007568 | aging |
| GO:0031100 | animal organ regeneration |
| GO:0003180 | aortic valve morphogenesis |
| GO:0006754 | ATP biosynthetic process |
| GO:0030509 | BMP signaling pathway |
| GO:0060751 | branch elongation involved in mammary gland duct branching |
| GO:0001775 | cell activation |
| GO:0007050 | cell cycle arrest |
| GO:0016477 | cell migration |
| GO:0008283 | cell population proliferation |
| GO:0045216 | cell-cell junction organization |
| GO:0006874 | cellular calcium ion homeostasis |
| GO:0071549 | cellular response to dexamethasone stimulus |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:1990314 | cellular response to insulin-like growth factor stimulus |
| GO:0071479 | cellular response to ionizing radiation |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0071560 | cellular response to transforming growth factor beta stimulus |
| GO:0002062 | chondrocyte differentiation |
| GO:0007182 | common-partner SMAD protein phosphorylation |
| GO:0061448 | connective tissue development |
| GO:0009817 | defense response to fungus, incompatible interaction |
| GO:0048565 | digestive tract development |
| GO:1990402 | embryonic liver development |
| GO:0007492 | endoderm development |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0085029 | extracellular matrix assembly |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0060325 | face morphogenesis |
| GO:0007565 | female pregnancy |
| GO:0060364 | frontal suture morphogenesis |
| GO:0008354 | germ cell migration |
| GO:0007507 | heart development |
| GO:0003179 | heart valve morphogenesis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0030214 | hyaluronan catabolic process |
| GO:0006954 | inflammatory response |
| GO:0048839 | inner ear development |
| GO:0070306 | lens fiber cell differentiation |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| GO:0097421 | liver regeneration |
| GO:0030324 | lung development |
| GO:0048535 | lymph node development |
| GO:0060744 | mammary gland branching involved in thelarche |
| GO:0030879 | mammary gland development |
| GO:0000165 | MAPK cascade |
| GO:0031293 | membrane protein intracellular domain proteolysis |
| GO:0007093 | mitotic cell cycle checkpoint |
| GO:0032943 | mononuclear cell proliferation |
| GO:0001763 | morphogenesis of a branching structure |
| GO:0046716 | muscle cell cellular homeostasis |
| GO:0042552 | myelination |
| GO:0043011 | myeloid dendritic cell differentiation |
| GO:0070168 | negative regulation of biomineral tissue development |
| GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| GO:0045786 | negative regulation of cell cycle |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0022408 | negative regulation of cell-cell adhesion |
| GO:0045918 | negative regulation of cytolysis |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0010629 | negative regulation of gene expression |
| GO:0060965 | negative regulation of gene silencing by miRNA |
| GO:1900126 | negative regulation of hyaluronan biosynthetic process |
| GO:0050777 | negative regulation of immune response |
| GO:0032700 | negative regulation of interleukin-17 production |
| GO:0010936 | negative regulation of macrophage cytokine production |
| GO:0045930 | negative regulation of mitotic cell cycle |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0007406 | negative regulation of neuroblast proliferation |
| GO:0030279 | negative regulation of ossification |
| GO:0050765 | negative regulation of phagocytosis |
| GO:1903799 | negative regulation of production of miRNAs involved in gene silencing by miRNA |
| GO:1903077 | negative regulation of protein localization to plasma membrane |
| GO:0001933 | negative regulation of protein phosphorylation |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol |
| GO:0048642 | negative regulation of skeletal muscle tissue development |
| GO:0050868 | negative regulation of T cell activation |
| GO:0042130 | negative regulation of T cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001843 | neural tube closure |
| GO:0021915 | neural tube development |
| GO:0007219 | Notch signaling pathway |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0014003 | oligodendrocyte development |
| GO:0043932 | ossification involved in bone remodeling |
| GO:0030316 | osteoclast differentiation |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0006796 | phosphate-containing compound metabolic process |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:2000727 | positive regulation of cardiac muscle cell differentiation |
| GO:0071158 | positive regulation of cell cycle arrest |
| GO:0051781 | positive regulation of cell division |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032270 | positive regulation of cellular protein metabolic process |
| GO:0050921 | positive regulation of chemotaxis |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0031536 | positive regulation of exit from mitosis |
| GO:0010763 | positive regulation of fibroblast migration |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0035066 | positive regulation of histone acetylation |
| GO:0031065 | positive regulation of histone deacetylation |
| GO:0032740 | positive regulation of interleukin-17 production |
| GO:0048298 | positive regulation of isotype switching to IgA isotypes |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0014008 | positive regulation of microglia differentiation |
| GO:0071677 | positive regulation of mononuclear cell migration |
| GO:1901666 | positive regulation of NAD+ ADP-ribosyltransferase activity |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| GO:0042482 | positive regulation of odontogenesis |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA |
| GO:0035307 | positive regulation of protein dephosphorylation |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:1900182 | positive regulation of protein localization to nucleus |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0050714 | positive regulation of protein secretion |
| GO:0031334 | positive regulation of protein-containing complex assembly |
| GO:1903911 | positive regulation of receptor clustering |
| GO:0045591 | positive regulation of regulatory T cell differentiation |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0051152 | positive regulation of smooth muscle cell differentiation |
| GO:0032930 | positive regulation of superoxide anion generation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0043117 | positive regulation of vascular permeability |
| GO:0006611 | protein export from nucleus |
| GO:0043491 | protein kinase B signaling |
| GO:0006468 | protein phosphorylation |
| GO:0032801 | receptor catabolic process |
| GO:2000249 | regulation of actin cytoskeleton reorganization |
| GO:0051098 | regulation of binding |
| GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis |
| GO:0061035 | regulation of cartilage development |
| GO:0001558 | regulation of cell growth |
| GO:0042127 | regulation of cell population proliferation |
| GO:0051101 | regulation of DNA binding |
| GO:0010468 | regulation of gene expression |
| GO:0032667 | regulation of interleukin-23 production |
| GO:0042306 | regulation of protein import into nucleus |
| GO:0045589 | regulation of regulatory T cell differentiation |
| GO:0060390 | regulation of SMAD protein signal transduction |
| GO:0002028 | regulation of sodium ion transport |
| GO:0016202 | regulation of striated muscle tissue development |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0045066 | regulatory T cell differentiation |
| GO:0070723 | response to cholesterol |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0009749 | response to glucose |
| GO:0001666 | response to hypoxia |
| GO:0035902 | response to immobilization stress |
| GO:0034616 | response to laminar fluid shear stress |
| GO:0014070 | response to organic cyclic compound |
| GO:0010033 | response to organic substance |
| GO:0032570 | response to progesterone |
| GO:0009314 | response to radiation |
| GO:1902074 | response to salt |
| GO:0033280 | response to vitamin D |
| GO:0009611 | response to wounding |
| GO:0007435 | salivary gland morphogenesis |
| GO:0007183 | SMAD protein complex assembly |
| GO:0060395 | SMAD protein signal transduction |
| GO:0042110 | T cell activation |
| GO:0030217 | T cell differentiation |
| GO:0043029 | T cell homeostasis |
| GO:0002513 | tolerance induction to self antigen |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:1905313 | transforming growth factor beta receptor signaling pathway involved in heart development |
| GO:0001657 | ureteric bud development |
| GO:0001570 | vasculogenesis |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| GO:0042060 | wound healing |