Gene: Edn2

Basic information

Tag Content
Uniprot ID P22389; Q9JME3;
Entrez ID 13615
Genbank protein ID CAA42155.1; BAA94208.1; AAH37042.1;
Genbank nucleotide ID NM_007902.3
Ensembl protein ID ENSMUSP00000030384
Ensembl nucleotide ID ENSMUSG00000028635
Gene name Endothelin-2
Gene symbol Edn2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 24043815
Functional description Vasoconstrictor.
Sequence
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS WLDKECVYFC 60
HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD SACATFCHRR HWPEAVVAPS 120
SQAPAAVLKT GKMWTAEGDL LRKLRDISAT KLRFARLQPE VTRKAIPAYS RWRKR 175

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEDN2319094Q867A9Bos taurusPredictionMore>>
1:1 orthologEDN2102181465A0A452FW37Capra hircusPredictionMore>>
1:1 orthologEDN21907P20800Homo sapiensPredictionMore>>
1:1 orthologEdn213615P22389CPOMus musculusPublicationMore>>
1:1 orthologEDN2H2PYT1Pan troglodytesPredictionMore>>
1:1 orthologEDN2A0A287A2W4Sus scrofaPredictionMore>>
1:1 orthologEdn224324G3V771Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005179 hormone activityISO
GO:0031708 endothelin B receptor bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001516 prostaglandin biosynthetic processISO
GO:0001516 prostaglandin biosynthetic processIDA
GO:0001543 ovarian follicle ruptureISO
GO:0001659 temperature homeostasisIMP
GO:0002690 positive regulation of leukocyte chemotaxisISO
GO:0003100 regulation of systemic arterial blood pressure by endothelinISO
GO:0007204 positive regulation of cytosolic calcium ion concentrationISO
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathwayISO
GO:0008217 regulation of blood pressureISO
GO:0008284 positive regulation of cell population proliferationISO
GO:0010460 positive regulation of heart rateISO
GO:0014824 artery smooth muscle contractionISO
GO:0014826 vein smooth muscle contractionISO
GO:0019221 cytokine-mediated signaling pathwayISO
GO:0019229 regulation of vasoconstrictionIEA
GO:0019722 calcium-mediated signalingISO
GO:0030593 neutrophil chemotaxisISO
GO:0042116 macrophage activationISO
GO:0042310 vasoconstrictionISO
GO:0045987 positive regulation of smooth muscle contractionISO
GO:0045987 positive regulation of smooth muscle contractionIDA
GO:0046887 positive regulation of hormone secretionISO
GO:0046888 negative regulation of hormone secretionISO
GO:0048016 inositol phosphate-mediated signalingISO
GO:0048246 macrophage chemotaxisISO
GO:0048286 lung alveolus developmentIMP
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activityISO
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activityIMP
GO:0097009 energy homeostasisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005615 extracellular spaceISO
GO:0005623 cellIEA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-373076 Class A/1 (Rhodopsin-like receptors)IEA
R-MMU-375276 Peptide ligand-binding receptorsIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-416476 G alpha (q) signalling eventsIEA
R-MMU-500792 GPCR ligand bindingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0165 Cleavage on pair of basic residues
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0838 Vasoactive
KW-0839 Vasoconstrictor

Interpro

InterPro ID InterPro Term
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
IPR015658 ET-2

PROSITE

PROSITE ID PROSITE Term
PS00270 ENDOTHELIN

Pfam

Pfam ID Pfam Term
PF00322 Endothelin

Protein-miRNA interaction