| Tag | Content |
|---|---|
| Uniprot ID | Q867A9 |
| Entrez ID | 319094 |
| Genbank protein ID | BAC55924.1 |
| Genbank nucleotide ID | NM_175714.2 |
| Ensembl protein ID | ENSBTAP00000028571 |
| Ensembl nucleotide ID | ENSBTAG00000021434 |
| Gene name | Endothelin-2 |
| Gene symbol | EDN2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Endothelins are endothelium-derived vasoconstrictor peptides. |
| Sequence | MPTALCSIAL ALLVALHEGK SQAATTPIPE QPAPLPRARG SHLRTRRCSC SSWLDKECVY 60 FCHLDIIWVN TPGQTAPYGL GNPPRRRRRS LPRRCECYSA RDPACATFCH QRPWTDAVAV 120 PGSGSPAAAF QDGKTQATAG ELLQRLRVIS ATKIHFARQQ QKPTRETRPT HSRQRKR 177 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDN2 | 319094 | Q867A9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDN2 | 102181465 | A0A452FW37 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDN2 | 1907 | P20800 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Edn2 | 13615 | P22389 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDN2 | H2PYT1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EDN2 | A0A287A2W4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Edn2 | 24324 | G3V771 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005615 | extracellular space |
| GO:0031708 | endothelin B receptor binding |
| GO:0005179 | hormone activity |
| GO:0014824 | artery smooth muscle contraction |
| GO:0019722 | calcium-mediated signaling |
| GO:0019221 | cytokine-mediated signaling pathway |
| GO:0097009 | energy homeostasis |
| GO:0048016 | inositol phosphate-mediated signaling |
| GO:0048286 | lung alveolus development |
| GO:0042116 | macrophage activation |
| GO:0048246 | macrophage chemotaxis |
| GO:0030593 | neutrophil chemotaxis |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| GO:0010460 | positive regulation of heart rate |
| GO:0002690 | positive regulation of leukocyte chemotaxis |
| GO:0060585 | positive regulation of prostaglandin-endoperoxide synthase activity |
| GO:0045987 | positive regulation of smooth muscle contraction |
| GO:0001516 | prostaglandin biosynthetic process |
| GO:0003100 | regulation of systemic arterial blood pressure by endothelin |
| GO:0019229 | regulation of vasoconstriction |
| GO:0001659 | temperature homeostasis |
| GO:0014826 | vein smooth muscle contraction |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00270 | ENDOTHELIN |
| Pfam ID | Pfam Term |
|---|---|
| PF00322 | Endothelin |