| Tag | Content |
|---|---|
| Uniprot ID | P36364 |
| Entrez ID | 25444 |
| Genbank protein ID | BAA03573.1 |
| Genbank nucleotide ID | NM_012952.1 |
| Ensembl protein ID | ENSRNOP00000015368 |
| Ensembl nucleotide ID | ENSRNOG00000011471 |
| Gene name | Fibroblast growth factor 9 |
| Gene symbol | Fgf9 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. |
| Sequence | MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 60 LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 120 KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 180 HQKFTHFLPR PVDPDKVPEL YKDILSQS 208 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF9 | 477340 | J9P0B3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 102169602 | A0A452FF06 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 100050353 | F7B6A2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 2254 | P31371 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fgf9 | 14180 | P54130 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF9 | 744731 | H2Q7A1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 396717 | Q95L12 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 100355861 | G1SDY3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgf9 | 25444 | P36364 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgf20b | 564770 | Q2LJ24 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0005104 | fibroblast growth factor receptor binding |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0001525 | angiogenesis |
| GO:0007267 | cell-cell signaling |
| GO:0002062 | chondrocyte differentiation |
| GO:0048566 | embryonic digestive tract development |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048706 | embryonic skeletal system development |
| GO:0001654 | eye development |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0042472 | inner ear morphogenesis |
| GO:0030324 | lung development |
| GO:0060484 | lung-associated mesenchyme development |
| GO:0008584 | male gonad development |
| GO:0030238 | male sex determination |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:1905931 | negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0001649 | osteoblast differentiation |
| GO:0032927 | positive regulation of activin receptor signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:0006606 | protein import into nucleus |
| GO:0048505 | regulation of timing of cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |