| Tag | Content |
|---|---|
| Uniprot ID | P54130; Q499I9; |
| Entrez ID | 14180 |
| Genbank protein ID | AAI25238.1; AAH99873.1; AAB36429.1; AAD49222.1; EDL36153.1; AAH99874.1; AAC52529.1; BAE34661.1; AAH99872.1; BAA07410.1; AAH99875.1; |
| Genbank nucleotide ID | NM_013518.4 |
| Ensembl protein ID | ENSMUSP00000022545 |
| Ensembl nucleotide ID | ENSMUSG00000021974 |
| Gene name | Fibroblast growth factor 9 |
| Gene symbol | Fgf9 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5, E16.5 |
| Data sources | Manually collected |
| Reference | 11493531; 12140681; |
| Functional description | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. |
| Sequence | MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 60 LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 120 KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 180 HQKFTHFLPR PVDPDKVPEL YKDILSQS 208 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF9 | 477340 | J9P0B3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 102169602 | A0A452FF06 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 100050353 | F7B6A2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 2254 | P31371 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fgf9 | 14180 | P54130 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF9 | 744731 | H2Q7A1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 396717 | Q95L12 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | FGF9 | 100355861 | G1SDY3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgf9 | 25444 | P36364 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgf20b | 564770 | Q2LJ24 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005104 | fibroblast growth factor receptor binding | ISO |
| GO:0008083 | growth factor activity | ISO |
| GO:0008201 | heparin binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0001525 | angiogenesis | IDA |
| GO:0001525 | angiogenesis | IMP |
| GO:0001649 | osteoblast differentiation | IMP |
| GO:0001654 | eye development | IMP |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IDA |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IMP |
| GO:0002062 | chondrocyte differentiation | IGI |
| GO:0002062 | chondrocyte differentiation | IMP |
| GO:0003214 | cardiac left ventricle morphogenesis | TAS |
| GO:0003231 | cardiac ventricle development | TAS |
| GO:0006606 | protein import into nucleus | IMP |
| GO:0007267 | cell-cell signaling | IMP |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0008284 | positive regulation of cell population proliferation | IDA |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | ISO |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IMP |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IGI |
| GO:0008584 | male gonad development | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010628 | positive regulation of gene expression | IDA |
| GO:0030178 | negative regulation of Wnt signaling pathway | IGI |
| GO:0030238 | male sex determination | IGI |
| GO:0030238 | male sex determination | IMP |
| GO:0030324 | lung development | IMP |
| GO:0030324 | lung development | IDA |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | IMP |
| GO:0032927 | positive regulation of activin receptor signaling pathway | IDA |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0043410 | positive regulation of MAPK cascade | ISO |
| GO:0045880 | positive regulation of smoothened signaling pathway | IDA |
| GO:0045880 | positive regulation of smoothened signaling pathway | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | TAS |
| GO:0048505 | regulation of timing of cell differentiation | IMP |
| GO:0048566 | embryonic digestive tract development | IMP |
| GO:0048706 | embryonic skeletal system development | IMP |
| GO:0050679 | positive regulation of epithelial cell proliferation | IDA |
| GO:0050679 | positive regulation of epithelial cell proliferation | IMP |
| GO:0051781 | positive regulation of cell division | IEA |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | IGI |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | IMP |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | TAS |
| GO:0060484 | lung-associated mesenchyme development | IMP |
| GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis | TAS |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | ISO |
| GO:1904754 | positive regulation of vascular associated smooth muscle cell migration | ISO |
| GO:1905931 | negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005604 | basement membrane | ISO |
| GO:0005615 | extracellular space | ISO |
| GO:0005737 | cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109704 | PI3K Cascade | IEA |
| R-MMU-112399 | IRS-mediated signalling | IEA |
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-190239 | FGFR3 ligand binding and activation | IEA |
| R-MMU-190241 | FGFR2 ligand binding and activation | IEA |
| R-MMU-190242 | FGFR1 ligand binding and activation | IEA |
| R-MMU-190322 | FGFR4 ligand binding and activation | IEA |
| R-MMU-190371 | FGFR3b ligand binding and activation | IEA |
| R-MMU-190372 | FGFR3c ligand binding and activation | IEA |
| R-MMU-190373 | FGFR1c ligand binding and activation | IEA |
| R-MMU-190375 | FGFR2c ligand binding and activation | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | IEA |
| R-MMU-2428924 | IGF1R signaling cascade | IEA |
| R-MMU-2428928 | IRS-related events triggered by IGF1R | IEA |
| R-MMU-5654219 | Phospholipase C-mediated cascade: FGFR1 | IEA |
| R-MMU-5654221 | Phospholipase C-mediated cascade; FGFR2 | IEA |
| R-MMU-5654227 | Phospholipase C-mediated cascade; FGFR3 | IEA |
| R-MMU-5654228 | Phospholipase C-mediated cascade; FGFR4 | IEA |
| R-MMU-5654687 | Downstream signaling of activated FGFR1 | IEA |
| R-MMU-5654688 | SHC-mediated cascade:FGFR1 | IEA |
| R-MMU-5654689 | PI-3K cascade:FGFR1 | IEA |
| R-MMU-5654693 | FRS-mediated FGFR1 signaling | IEA |
| R-MMU-5654695 | PI-3K cascade:FGFR2 | IEA |
| R-MMU-5654696 | Downstream signaling of activated FGFR2 | IEA |
| R-MMU-5654699 | SHC-mediated cascade:FGFR2 | IEA |
| R-MMU-5654700 | FRS-mediated FGFR2 signaling | IEA |
| R-MMU-5654704 | SHC-mediated cascade:FGFR3 | IEA |
| R-MMU-5654706 | FRS-mediated FGFR3 signaling | IEA |
| R-MMU-5654708 | Downstream signaling of activated FGFR3 | IEA |
| R-MMU-5654710 | PI-3K cascade:FGFR3 | IEA |
| R-MMU-5654712 | FRS-mediated FGFR4 signaling | IEA |
| R-MMU-5654716 | Downstream signaling of activated FGFR4 | IEA |
| R-MMU-5654719 | SHC-mediated cascade:FGFR4 | IEA |
| R-MMU-5654720 | PI-3K cascade:FGFR4 | IEA |
| R-MMU-5654726 | Negative regulation of FGFR1 signaling | IEA |
| R-MMU-5654727 | Negative regulation of FGFR2 signaling | IEA |
| R-MMU-5654732 | Negative regulation of FGFR3 signaling | IEA |
| R-MMU-5654733 | Negative regulation of FGFR4 signaling | IEA |
| R-MMU-5654736 | Signaling by FGFR1 | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-5654741 | Signaling by FGFR3 | IEA |
| R-MMU-5654743 | Signaling by FGFR4 | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-74751 | Insulin receptor signalling cascade | IEA |
| R-MMU-74752 | Signaling by Insulin receptor | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |