| Tag | Content |
|---|---|
| Uniprot ID | P54842 |
| Entrez ID | 54264 |
| Genbank protein ID | AAB50062.1 |
| Genbank nucleotide ID | NM_019316.1 |
| Ensembl protein ID | ENSRNOP00000021452 |
| Ensembl nucleotide ID | ENSRNOG00000016037 |
| Gene name | Transcription factor MafB |
| Gene symbol | Mafb |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity). Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). |
| Sequence | MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL 60 STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP 120 LQSFDGFRSA HHHHHHHHPH PHHGYPGAGV THDELGPHAH PHHHHHHQAS PPPSSAASPA 180 QQLPTSHPGP GPHAAAAATA AGSNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK 240 QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 300 LANSGFREAG STSDSPSSPE FFL 323 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MAFB | 532376 | F1N054 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MAFB | A0A452EFD6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MAFB | 9935 | Q9Y5Q3 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mafb | 16658 | P54841 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MAFB | 469941 | H2R8Y7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TQX0 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mafb | 54264 | P54842 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mafb | Q98UK5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0042025 | host cell nucleus |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:0044877 | protein-containing complex binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:1990837 | sequence-specific double-stranded DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0021599 | abducens nerve formation |
| GO:0035284 | brain segmentation |
| GO:0045444 | fat cell differentiation |
| GO:0042472 | inner ear morphogenesis |
| GO:0045647 | negative regulation of erythrocyte differentiation |
| GO:0045671 | negative regulation of osteoclast differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0007585 | respiratory gaseous exchange by respiratory system |
| GO:0021571 | rhombomere 5 development |
| GO:0021572 | rhombomere 6 development |
| GO:0007379 | segment specification |
| GO:0033077 | T cell differentiation in thymus |
| GO:0048538 | thymus development |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50217 | BZIP |