| Tag | Content |
|---|---|
| Uniprot ID | Q98UK5; O73679; |
| Entrez ID | |
| Genbank protein ID | BAB21102.1; AAC18821.1; AAI17641.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000152024 |
| Ensembl nucleotide ID | ENSDARG00000017121 |
| Gene name | Transcription factor MafB |
| Gene symbol | mafb |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. |
| Sequence | MSADLAMGPE LPTSPLALEY VNDFDLMKFE VKKEAMAAHD RANIRQCNRL QPQGSVSSTP 60 ISTPCSSVPS SPSFSPTEQK NHLEELYWMP SGAYPQQIDP QTLSLTPEDA VEALIGATAH 120 GHPPPPHVQQ QLQAGAFDGY RGAHHHHGHA QQQQQQQPQH HHHQHQYGAI PHHPDDLSGH 180 PGAHGHHPHH HHHHHHSQDP DSPSPTSPEQ LHHRHHHHHH PHGHPGQQGH HGVGGGLNVE 240 DRFSDDQLVT MSVRELNRHL RGFTKDEVIR LKQKRRTLKN RGYAQSCRFK RVQQKHLLEN 300 EKTQLINQVE QLKQEINRLA RERDAYKLKC EKLTGANGFR EAGSTSDNPS SPEFFM 356 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MAFB | 532376 | F1N054 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MAFB | A0A452EFD6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MAFB | 9935 | Q9Y5Q3 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mafb | 16658 | P54841 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MAFB | 469941 | H2R8Y7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TQX0 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mafb | 54264 | P54842 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mafb | Q98UK5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0021742 | abducens nucleus development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0009880 | embryonic pattern specification |
| GO:0001946 | lymphangiogenesis |
| GO:0039021 | pronephric glomerulus development |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0021571 | rhombomere 5 development |
| GO:0021572 | rhombomere 6 development |
| GO:0021654 | rhombomere boundary formation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50217 | BZIP |