| Tag | Content |
|---|---|
| Uniprot ID | P70372; Q60745; Q78QY3; |
| Entrez ID | 15568 |
| Genbank protein ID | EDL21997.1; AAA96941.1; EDL21996.1; AAB17967.1; BAC37892.1; |
| Genbank nucleotide ID | NM_010485.3; XM_006508698.3; |
| Ensembl protein ID | ENSMUSP00000146866; ENSMUSP00000096549; |
| Ensembl nucleotide ID | ENSMUSG00000040028 |
| Gene name | ELAV-like protein 1 |
| Gene symbol | Elavl1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19307312 |
| Functional description | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed:24394384). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:27616329). |
| Sequence | MSNGYEDHMA EDCRDDIGRT NLIVNYLPQN MTQEELRSLF SSIGEVESAK LIRDKVAGHS 60 LGYGFVNYVT AKDAERAIST LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK 120 DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT 180 VKFAANPNQN KNMALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG ISGVNVPGNA 240 SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM 300 AIASLNGYRL GDKILQVSFK TNKSHK 326 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ELAVL1 | 617316 | Q3ZCE2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ELAVL1 | 102173732 | A0A452EKQ9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ELAVL1 | F6VTW3 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | ELAVL1 | 1994 | Q15717 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Elavl1 | 15568 | P70372 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ELAVL1 | 743010 | K7D3Q8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ELAVL1 | 100337681 | D3K5N7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Elavl1 | 363854 | B5DF91 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003723 | RNA binding | ISS |
| GO:0003723 | RNA binding | ISO |
| GO:0003725 | double-stranded RNA binding | ISO |
| GO:0003729 | mRNA binding | IDA |
| GO:0003730 | mRNA 3'-UTR binding | ISO |
| GO:0003730 | mRNA 3'-UTR binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0017091 | AU-rich element binding | ISS |
| GO:0017091 | AU-rich element binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0035198 | miRNA binding | ISS |
| GO:0035198 | miRNA binding | ISO |
| GO:0035925 | mRNA 3'-UTR AU-rich region binding | ISS |
| GO:0035925 | mRNA 3'-UTR AU-rich region binding | ISO |
| GO:0035925 | mRNA 3'-UTR AU-rich region binding | IDA |
| GO:0042803 | protein homodimerization activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006606 | protein import into nucleus | IMP |
| GO:0045727 | positive regulation of translation | IDA |
| GO:0045727 | positive regulation of translation | IMP |
| GO:0045727 | positive regulation of translation | ISO |
| GO:0048255 | mRNA stabilization | ISS |
| GO:0048255 | mRNA stabilization | ISO |
| GO:0048255 | mRNA stabilization | IMP |
| GO:0048255 | mRNA stabilization | IDA |
| GO:0051260 | protein homooligomerization | ISS |
| GO:0051260 | protein homooligomerization | ISO |
| GO:0060965 | negative regulation of gene silencing by miRNA | ISS |
| GO:0060965 | negative regulation of gene silencing by miRNA | ISO |
| GO:0070935 | 3'-UTR-mediated mRNA stabilization | ISS |
| GO:0070935 | 3'-UTR-mediated mRNA stabilization | ISO |
| GO:0070935 | 3'-UTR-mediated mRNA stabilization | IDA |
| GO:2000036 | regulation of stem cell population maintenance | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISS |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | ISO |
| GO:0010494 | cytoplasmic stress granule | IDA |
| GO:0098794 | postsynapse | IDA |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:1990904 | ribonucleoprotein complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-450520 | HuR (ELAVL1) binds and stabilizes mRNA | IEA |
| R-MMU-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | IEA |
| R-MMU-72163 | mRNA Splicing - Major Pathway | IEA |
| R-MMU-72172 | mRNA Splicing | IEA |
| R-MMU-72203 | Processing of Capped Intron-Containing Pre-mRNA | IEA |
| R-MMU-8953854 | Metabolism of RNA | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50102 | RRM |
| Pfam ID | Pfam Term |
|---|---|
| PF00076 | RRM_1 |