| Tag | Content |
|---|---|
| Uniprot ID | P83095 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Serine beta-lactamase-like protein LACTB, mitochondrial |
| Gene symbol | LACTB |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. |
| Sequence | MYRLLSAVMA RAATTGGCAW GCGRRAAHQR AGLPPLGPGW VGGLGLGLGL ALGVKLAGGL 60 RGASPAPPAA APDPEALPQA EPLQAQEQPL APWSPQTPAP PHTRHFARAI DSSRDLLHRI 120 KDEVGAPGIV VGVSVDGKEV WSEGLGYADV ENRVPCKPET VMRIASISKS LTMVAIAKLW 180 EAGKLDLDIP VQHYVPEFPE KEYEGEKVSV TTRLLISHLS GIRHYEKDMK KVKEEKAYKA 240 LKMMKEMMES DQEKELKEKG GKSNEKNDFA KAKVEQDNET KGRNSKPCKK KNDFEQGELY 300 LKEKFENSIE SLRLFKNDPL FFKPGSQFLY STFGYTLLAA IVERASGYKY LDYMQKIFHD 360 LDMLTTVQEE NEPVIYNRAR FYVYNKKKRL VNTPYVDNSY KWAGGGFLST VGDLLKFGNA 420 MLYGYQVGLF KNANENLLPG YLKPETMLMI WTPVPNTEMS WDKEGKYAMA WGVVEKKQTY 480 GSCRKQRHYA SHTGGAVGAS SVLLVLPEEL DAEALNNKVP PRGIVVSIIC NMQSVGLNST 540 ALKIALEFDK DRSDIP 556 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LACTB | P83095 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | LACTB | 102172902 | A0A452GAH4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 114294 | P83111 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Lactb | 80907 | Q9EP89 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 453496 | K7CYM3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 100152773 | F1S089 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | LACTB | G1SYC1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Lactb | 300803 | D3ZFJ6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lactb | F1QPG1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005739 | mitochondrion |
| GO:0008233 | peptidase activity |
| GO:0006629 | lipid metabolic process |
| GO:0006508 | proteolysis |
| GO:0019216 | regulation of lipid metabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00144 | Beta-lactamase |