| Tag | Content |
|---|---|
| Uniprot ID | Q9EP89 |
| Entrez ID | 80907 |
| Genbank protein ID | AAG37911.1; AAG37910.1; |
| Genbank nucleotide ID | NM_030717.1 |
| Ensembl protein ID | ENSMUSP00000034929 |
| Ensembl nucleotide ID | ENSMUSG00000032370 |
| Gene name | Serine beta-lactamase-like protein LACTB, mitochondrial |
| Gene symbol | Lactb |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). |
| Sequence | MYRLLSSVTA RAAATAGPAW DGGRRGAHRR PGLPVLGLGW AGGLGLGLGL ALGAKLVVGL 60 RGAVPIQSPA DPEASGTTEL SHEQALSPGS PHTPAPPAAR GFSRAIESSR DLLHRIKDEV 120 GAPGIVVGVS VDGKEVWSEG LGYADVENRV PCKPETVMRI ASISKSLTMV ALAKLWEAGK 180 LDLDLPVQHY VPEFPEKEYE GEKVSVTTRL LISHLSGIRH YEKDIKKVKE EKAYKALKMV 240 KGTPPPSDQE KELKEKGGKN NEKSDAPKAK VEQDSEARCR SAKPGKKKND FEQGELYLKE 300 KFENSIESLR LFKNDPLFFK PGSQFLYSTF GYTLLAAIVE RASGYKYLDY MQKIFHDLDM 360 LTTVQEENEP VIYNRARFYV YNKKKRLVNT PYVDNSYKWA GGGFLSTVGD LLKFGNAMLY 420 GYQVGQFKNS NENLLPGYLK PETMVMMWTP VPNTEMSWDK EGKYAMAWGV VEKKQTYGSC 480 RKQRHYASHT GGAVGASSVL LVLPEELDSE AVNNKVPPRG IIVSIICNMQ SVGLNSTALK 540 IALEFDKDRA D 551 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LACTB | P83095 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | LACTB | 102172902 | A0A452GAH4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 114294 | P83111 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Lactb | 80907 | Q9EP89 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 453496 | K7CYM3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LACTB | 100152773 | F1S089 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | LACTB | G1SYC1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Lactb | 300803 | D3ZFJ6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lactb | F1QPG1 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| LACTB | c.15C>T; p.M5I | WES and Sanger sequencing | 26449438 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0008233 | peptidase activity | ISS |
| GO:0008233 | peptidase activity | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006508 | proteolysis | ISS |
| GO:0006508 | proteolysis | ISO |
| GO:0006629 | lipid metabolic process | IEA |
| GO:0019216 | regulation of lipid metabolic process | ISS |
| GO:0019216 | regulation of lipid metabolic process | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | HDA |
| GO:0005829 | cytosol | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00144 | Beta-lactamase |