| Tag | Content |
|---|---|
| Uniprot ID | P86046 |
| Entrez ID | 100040591 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001110227.2 |
| Ensembl protein ID | ENSMUSP00000108838 |
| Ensembl nucleotide ID | ENSMUSG00000079436 |
| Gene name | Inward rectifier potassium channel 13 |
| Gene symbol | Kcnj13 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E15.5, E18.5 |
| Data sources | Manually collected |
| Reference | 26402555 |
| Functional description | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium (By similarity). |
| Sequence | MDSSNCKVNA PLLSQRHRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD MRWRWMMLVF 60 SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV KHITSFTAAF SFSLETQLTI 120 GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDLAVVAH 180 KDGKPNLIFQ VANTRPSPLT NVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP 240 LTYYHTISPS SPLATLLQHE TPPHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA 300 ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN FQIAETGLTE 360 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KCNJ13 | 512288 | E1BN00 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 477411 | E2R7P4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 102188013 | A0A452F407 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 100057299 | F7CJ39 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 3769 | O60928 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kcnj13 | 100040591 | P86046 | CPO | E15.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | KCNJ13 | 100615579 | A0A2J8NEW2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 100151780 | I3LPQ3 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | KCNJ13 | 100009492 | G1SJT5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kcnj13 | 94341 | O70617 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kcnj13 | 555691 | Q0KIZ7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005242 | inward rectifier potassium channel activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0034765 | regulation of ion transmembrane transport | IBA |
| GO:1990573 | potassium ion import across plasma membrane | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0016021 | integral component of membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|