| Tag | Content |
|---|---|
| Uniprot ID | Q14AT2; Q8BUS0; Q99MW9; |
| Entrez ID | 83558 |
| Genbank protein ID | AAK31951.1; BAC38624.1; AAI16710.1; |
| Genbank nucleotide ID | NM_001167997.1; NM_031384.2; |
| Ensembl protein ID | ENSMUSP00000109347; ENSMUSP00000009814; ENSMUSP00000109345; |
| Ensembl nucleotide ID | ENSMUSG00000009670 |
| Gene name | Testis-expressed protein 11 |
| Gene symbol | Tex11 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. |
| Sequence | MDRITDFYFL DFRESVKTLI ITGNSWRLQE MIDRFFTNIS NFNRESLTEI QNIQIEEIAV 60 NLWNWAVTKR VELSVRKNQA AKLCYIACKL VYMHGISVSS EEAIQRQILM NIKTGKEWLY 120 TGNAQIADEF FQAAMTDLER LYVRLMQSCY TEANVCVYKM IVEKGIFHVL SYQAESAVAQ 180 GDFKKASMCV LRCKDMLMRL PNMTKYLHVL CYNLGIEASK RNKYKESSFW LGQSYEIGKM 240 DRRSVEPQML AKTLRLLATI YLNCGGEAYY TKAFIAILIA NKEHLHPAGL FLKMRILMKG 300 NSCNEELLEA AKEILYLAMP LEFYLSIIQF LIDNKRESVG FRFLRIISDN FKSPEDRKRI 360 LLFYIDTLLQ KDQDMIAEEK IKDVLKGYQT RSRLSRDLVN WLHNILWGKA SRSVKVQKYA 420 DALHWYSYSL KLYEYDKADL DLIKLKRNMV SCYLSLKQLD KAKEAIAEVE QKDPTHVFTR 480 YYIFKIAIME GDAFRALQVV SALKKSLMDG ESEDRGLIEA GVSTLTILSL SIDFALENGQ 540 QFVAERALEY LCQLSKDPKE VLGGLKCLMR IILPQAFHMP ESEYKKKEMG RLWNYLNTAL 600 LKFSEYFNEA PSTLDYMVND ANWFRKIAWN LAVQSEKDLE AMKNFFMVSY KLSLFCPLDQ 660 GLLIAQKTCL LVAAAVDLDR GRKAPTICEQ NMLLRTALEQ IKKCKKVWNL LKKTGDFSGD 720 DCGVLLLLYE FEVKTKTNDP SLSRFVDSVW KMPDLECRTL ETMALLAMDK PAYYPTIAHK 780 AMKKLLLMYR KQEPVDVLKY SVCMHNLIKL LVADEVWNIS LYPLKEVQSH FKNTLSIIRQ 840 NEGYPEEEIV WLMIKSWNIG ILMSSKNKYI SAERWAAMAL DFLGHLSTLK TSYEAKVNLL 900 YANLMEILDK KTDLRSTEMT EQLRALIVPP EDQGSVSSTN VAAQNHL 947 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TEX11 | 56159 | Q8IYF3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tex11 | 83558 | Q14AT2 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TEX11 | H2R4P5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Tex11 | D3Z868 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tex11 | F1QIP8 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| TEX11 | c.2541A>C; p.D847E | WES and Sanger sequencing | 26449438 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000712 | resolution of meiotic recombination intermediates | IMP |
| GO:0006311 | meiotic gene conversion | IMP |
| GO:0007060 | male meiosis chromosome segregation | IMP |
| GO:0007060 | male meiosis chromosome segregation | IBA |
| GO:0007130 | synaptonemal complex assembly | IMP |
| GO:0007130 | synaptonemal complex assembly | IBA |
| GO:0007131 | reciprocal meiotic recombination | IMP |
| GO:0007131 | reciprocal meiotic recombination | IBA |
| GO:0007140 | male meiotic nuclear division | IMP |
| GO:0008584 | male gonad development | IMP |
| GO:0009566 | fertilization | IMP |
| GO:0043066 | negative regulation of apoptotic process | IMP |
| GO:0051026 | chiasma assembly | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000794 | condensed nuclear chromosome | IDA |
| GO:0000801 | central element | IDA |
| GO:0000801 | central element | IBA |
| GO:0000795 | synaptonemal complex | IDA |
| GO:0000795 | synaptonemal complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF08631 | SPO22 |