| Tag | Content |
|---|---|
| Uniprot ID | Q1JPY5; Q6RIA7; |
| Entrez ID | 414331 |
| Genbank protein ID | AAI64033.1; AAI16553.1; AAR89625.1; |
| Genbank nucleotide ID | NM_001001730.2 |
| Ensembl protein ID | ENSDARP00000062550 |
| Ensembl nucleotide ID | ENSDARG00000042641 |
| Gene name | Lanosterol 14-alpha demethylase |
| Gene symbol | cyp51 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. |
| Sequence | MTILEVGSQL IESAVLQMSL TSVLLTASVF TLTLGYFSKL LFTQHSSEHT KYPPHIPSSL 60 PFLGQAVAFG RSPIEFLEKA YEQYGPVVSF TMVGKTFTYL LGSDAAALMF NSKNEDLNAE 120 DVYARLTTPV FGKGVAYDVP NPLFLEQKKM LKTGLNIAQF KQHVEIIEEE TKDYFRRWGE 180 SGERNLFDAL SELIILTASR CLHGCEIRSL LDERVAQLYA DLDGGFTHAA WLLPGWLPLP 240 SFRRRDRAHL EIKKIFYNVI KKRREDTEKH DDILQTLIDA TYKDGRPLSD DEIAGMLIGL 300 LLAGQHTSST TSAWMGFFLA RDRALQERCY SEQKSVCGEE LPPLHYDQLK DLSLLDRCLK 360 ETLRLRPPIM TMMRMAKTPQ KVGEYTIPPG HQVCVSPTVN HRLQDTWAER LDFDPDRYLH 420 DNPAAGEKFA YIPFGAGRHR CIGENFAYVQ IKTIWSTLLR MFDFELVDGH FPPVNYTTMI 480 HTPHNPIIRY TRRNTQPQQ 499 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP51A1 | 505060 | Q4PJW3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP51A1 | 102177400 | A0A452E234 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP51A1 | 1595 | A0A0C4DFL7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cyp51a1 | 13121 | Q8K0C4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CYP51A1 | 403334 | O46420 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Cyp51a1 | 25427 | Q64654 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cyp51 | 414331 | Q1JPY5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0020037 | heme binding |
| GO:0005506 | iron ion binding |
| GO:0004497 | monooxygenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0008398 | sterol 14-demethylase activity |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0001878 | response to yeast |
| GO:0016125 | sterol metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0152 | Cholesterol biosynthesis |
| KW-0153 | Cholesterol metabolism |
| KW-0256 | Endoplasmic reticulum |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0503 | Monooxygenase |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0753 | Steroid metabolism |
| KW-0756 | Sterol biosynthesis |
| KW-1207 | Sterol metabolism |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |