| Tag | Content |
|---|---|
| Uniprot ID | Q1JQA2; Q06AL6; |
| Entrez ID | 540488 |
| Genbank protein ID | ABI96185.1; AAI16118.1; |
| Genbank nucleotide ID | NM_001076223.2; XM_010813715.2; XM_005217509.2; XM_010813716.2; XM_005217511.2; |
| Ensembl protein ID | ENSBTAP00000003668; ENSBTAP00000057918; ENSBTAP00000067920; ENSBTAP00000074456; |
| Ensembl nucleotide ID | ENSBTAG00000002835 |
| Gene name | Mothers against decapentaplegic homolog 1 |
| Gene symbol | SMAD1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. |
| Sequence | MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ 60 PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV 120 CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN 180 SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ 240 PMDTNMMAPS LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 300 DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 360 NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW 420 GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS 465 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD1 | 540488 | Q1JQA2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMAD1 | 475456 | E2QZF1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SMAD1 | A0A452E7S9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SMAD1 | 100033850 | F6W0G0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SMAD1 | 4086 | Q15797 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Smad1 | 17125 | P70340 | E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | SMAD1 | H2QQ88 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SMAD1 | 397016 | Q864V7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SMAD1 | 100341544 | A0A5F9CKV6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad1 | A0A0G2JSQ6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005637 | nuclear inner membrane |
| GO:0005667 | transcription factor complex |
| GO:0070410 | co-SMAD binding |
| GO:0017151 | DEAD/H-box RNA helicase binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0070411 | I-SMAD binding |
| GO:0042802 | identical protein binding |
| GO:0046872 | metal ion binding |
| GO:0070878 | primary miRNA binding |
| GO:0019901 | protein kinase binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0030509 | BMP signaling pathway |
| GO:0060348 | bone development |
| GO:0060038 | cardiac muscle cell proliferation |
| GO:0051216 | cartilage development |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0007276 | gamete generation |
| GO:0030902 | hindbrain development |
| GO:0042592 | homeostatic process |
| GO:0006954 | inflammatory response |
| GO:0000165 | MAPK cascade |
| GO:0001710 | mesodermal cell fate commitment |
| GO:0030901 | midbrain development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0002051 | osteoblast fate commitment |
| GO:0061036 | positive regulation of cartilage development |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| GO:1903672 | positive regulation of sprouting angiogenesis |
| GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| GO:0007183 | SMAD protein complex assembly |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0001657 | ureteric bud development |