Gene: Pgap2

Basic information

Tag Content
Uniprot ID Q3TQR0; Q3TVW2; Q3U814; Q3UJI0; Q99KA1;
Entrez ID 233575
Genbank protein ID BAE31205.1; BAE35506.1; BAE22083.1; AAH04794.1; BAE35494.1; BAE37322.1; BAE27175.1;
Genbank nucleotide ID XM_006507645.2; XM_006507650.3; XM_006507643.3; XM_006507646.2; XM_006507651.3; XM_006507644.3; NM_001291358.1; NM_145583.3;
Ensembl protein ID ENSMUSP00000114016; ENSMUSP00000033292; ENSMUSP00000121521;
Ensembl nucleotide ID ENSMUSG00000030990
Gene name Post-GPI attachment to proteins factor 2
Gene symbol Pgap2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO,CLP,CLO
Developmental stage
Data sources Manually collected
Reference 21515572; 31232685;
Functional description Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
Sequence
MYQVPLTLDR DGTLVRLRFT MVALITVCCP LVAFFFCILW SLLFHFKETT STHCGVPNYL 60
PSVSSAIGGE VPQRYVWRFC IGLHSAPRFL TAFAYWNHYL SCASPCPGYR LLCRINFSLN 120
VVENLALLVL TYVSSSEDFT IHENAFIVFI AASLGYMLLT CILWRLTKKH TVSQEDRKSY 180
SWKQRLFVIN FISFFSALAV YFRHNMYCEA GVYTIFAILE YTVVLTNMAF HMTAWWDFGN 240
KELLITSQPE EKRF 254

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPGAP2540520A6H7B8Bos taurusPredictionMore>>
1:1 orthologPGAP2102190338A0A452GA35Capra hircusPredictionMore>>
1:1 orthologPGAP2100053037A0A3Q2HNJ2Equus caballusPredictionMore>>
1:1 orthologPGAP227315Q9UHJ9Homo sapiensPredictionMore>>
1:1 orthologPgap2233575Q3TQR0CPO,CLP,CLOMus musculusPublicationMore>>
1:1 orthologPGAP2743877K7AX68Pan troglodytesPredictionMore>>
1:1 orthologPGAP2A0A286ZK90Sus scrofaPredictionMore>>
1:1 orthologPgap2D4ACY7Rattus norvegicusPredictionMore>>
1:1 orthologpgap2541417G1K2N7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence
GO:0006506 GPI anchor biosynthetic processISS
GO:0006506 GPI anchor biosynthetic processISO
GO:0006506 GPI anchor biosynthetic processIBA
GO:0072659 protein localization to plasma membraneISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0000139 Golgi membraneISS
GO:0000139 Golgi membraneISO
GO:0005789 endoplasmic reticulum membraneISS
GO:0005789 endoplasmic reticulum membraneISO
GO:0005789 endoplasmic reticulum membraneIBA
GO:0016021 integral component of membraneIEA
GO:0005783 endoplasmic reticulumISO
GO:0005794 Golgi apparatusISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0256 Endoplasmic reticulum
KW-0333 Golgi apparatus
KW-0337 GPI-anchor biosynthesis
KW-0472 Membrane
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR019402 Frag1/DRAM/Sfk1
IPR039545 PGAP2

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF10277 Frag1

Protein-miRNA interaction