| Tag | Content |
|---|---|
| Uniprot ID | Q4VBD2; Q8CDI4; |
| Entrez ID | 231225 |
| Genbank protein ID | BAC26728.1; AAH96038.1; |
| Genbank nucleotide ID | NM_173764.3 |
| Ensembl protein ID | ENSMUSP00000062110 |
| Ensembl nucleotide ID | ENSMUSG00000046985 |
| Gene name | Transmembrane anterior posterior transformation protein 1 |
| Gene symbol | Tapt1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 27933520 |
| Functional description | Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). |
| Sequence | MAGVCDAAAP GEGGGGGADG PERTGRGEAE QPGGGGHGPA PQHTETLGFY ESDRRREKRR 60 GRAELSLLRF LSAELTRGYF LEHNEAKYTE RRERVYTCMR IPRELEKLMF FGIFLCLDAF 120 LYVFTLLPLR VFLALFRLLT LPCYGLRDRR LLQPAQVCDI LKGVILVICY FMMHYVDYSM 180 MYHLIRGQSV IKLYIIYNML EVADRLFSSF GQDILDALYW TATEPKERKR AHIGVIPHFF 240 MAVLYVFLHA ILIMVQATTL NVAFNSHNKS LLTIMMSNNF VEIKGSVFKK FEKNNLFQMS 300 NSDIKERFTN YVLLLIVCLR NMEQFSWNPD HLWVLFPDVC MVIASEIAVD IVKHAFITKF 360 NDITADVYSE YRASLAFDLV SSRQKNAYTD YSDSVARRMG FIPLPLAVLL IRVVTSSIKV 420 QGILSYACVI LFYFGLISLK ILNSIVLLGK SCQYVKEAKM EEKLFNPPPA STPGKPSSKS 480 QSKGKPSQGL STEENLSASV TSQPGHQKEN VIPLLVTSNS DQFLTTPDGD EKDITQENSE 540 LKHRSSKKDL LEIDRFTICG NRID 564 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TAPT1 | A0A5F4CM65 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TAPT1 | A0A452EHE5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TAPT1 | 202018 | Q6NXT6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tapt1 | 231225 | Q4VBD2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TAPT1 | H2RC85 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TAPT1 | A0A287A5J1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tapt1 | D4A533 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001503 | ossification | IEA |
| GO:0014032 | neural crest cell development | ISS |
| GO:0030030 | cell projection organization | IEA |
| GO:0035437 | maintenance of protein localization in endoplasmic reticulum | IBA |
| GO:0045724 | positive regulation of cilium assembly | ISS |
| GO:0045724 | positive regulation of cilium assembly | ISO |
| GO:0045724 | positive regulation of cilium assembly | IBA |
| GO:0048706 | embryonic skeletal system development | IMP |
| GO:0048856 | anatomical structure development | IMP |
| GO:0051216 | cartilage development | IEA |
| GO:0061036 | positive regulation of cartilage development | ISS |
| GO:1903012 | positive regulation of bone development | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005783 | endoplasmic reticulum | IBA |
| GO:0005813 | centrosome | ISS |
| GO:0005813 | centrosome | ISO |
| GO:0030176 | integral component of endoplasmic reticulum membrane | IBA |
| GO:0036064 | ciliary basal body | ISS |
| GO:0036064 | ciliary basal body | ISO |
| GO:0036064 | ciliary basal body | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0966 | Cell projection |
| KW-0891 | Chondrogenesis |
| KW-0969 | Cilium |
| KW-0970 | Cilium biogenesis/degradation |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-0472 | Membrane |
| KW-0892 | Osteogenesis |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR008010 | Tatp1 |
| Pfam ID | Pfam Term |
|---|---|
| PF05346 | DUF747 |