CleftGeneDB-Search

Gene: ZNF385B

Basic information

Tag	Content
Uniprot ID	Q569K4; Q49A04; Q6ZMZ7; Q8IY01; Q8N8H2; Q96DK4;
Entrez ID	151126
Genbank protein ID	AAH48123.1; BAD18578.1; BAB71629.1; AAH92423.1; BAC04870.1; AAH38422.1;
Genbank nucleotide ID	XM_017003438.1; NM_001282725.1; XM_017003439.1; NM_152520.4; NM_001113398.1; NM_001113397.1;
Ensembl protein ID	ENSP00000386379; ENSP00000338225; ENSP00000386507;
Ensembl nucleotide ID	ENSG00000144331
Gene name	Zinc finger protein 385B
Gene symbol	ZNF385B
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	20849254; 16953426;
Functional description	May play a role in p53/TP53-mediated apoptosis.
Sequence	MNMANFLRGF EEKGIKNDRP EDQLSKEKKK ILFSFCEVCN IQLNSAAQAQ VHSNGKSHRK 60 RVKQLSDGQP PPPAQASPSS NSSTGSTCHT TTLPALVRTP TLMMQPSLDI KPFMSFPVDS 120 SSAVGLFPNF NTMDPVQKAV INHTFGVSIP PKKKQVISCN VCQLRFNSDS QAEAHYKGSK 180 HAKKVKALDA TKNKPKMVPS KDSAKANPSC SITPITGNNS DKSEDKGKLK ASSSSQPSSS 240 ESGSFLLKSG TTPLPPGAAT SPSKSTNGAP GTVVESEEEK AKKLLYCSLC KVAVNSLSQL 300 EAHNTGSKHK TMVEARNGAG PIKSYPRPGS RLKMQNGSKG SGLQNKTFHC EICDVHVNSE 360 IQLKQHISSR RHKDRVAGKP LKPKYSPYNK LQRSPSILAA KLAFQKDMMK PLAPAFLSSP 420 LAAAAAVSSA LSLPPRPSAS LFQAPAIPPA LLRPGHGPIR ATPASILFAP Y 471

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	ZNF385B	613328	A4FUW9		Bos taurus	Prediction	More>>
1:1 ortholog	ZNF385B		A0A452FYI9		Capra hircus	Prediction	More>>
1:1 ortholog	ZNF385B	151126	Q569K4	CPO,CL/P	Homo sapiens	Publication	More>>
1:1 ortholog	Znf385b	241494	Q8BXJ8		Mus musculus	Prediction	More>>
1:1 ortholog	Zfp385b		A0A0G2K4A6		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
VAR_053765	p.Ser242Gly	Missense	-	-	UniProt
VAR_076447	p.Phe416Tyr	Missense	-	-	UniProt

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0008925	Cleft Palate	disease	BEFREE
C0025362	Mental Retardation	disease	BEFREE
C0028754	Obesity	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0265354	CHARGE Syndrome	disease	BEFREE
C1720824	Sudden Cardiac Arrest	phenotype	GWASCAT;GWASDB
C1837218	Cleft palate, isolated	disease	BEFREE
C2981150	Uranostaphyloschisis	disease	BEFREE
C3714756	Intellectual Disability	group	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0002039	p53 binding	IPI
GO:0003676	nucleic acid binding	IEA
GO:0008270	zinc ion binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IBA
GO:0005634	nucleus	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in decreased expression of ZNF385B mRNA	20406850
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ZNF385B mRNA	28973690
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ZNF385B mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ZNF385B mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ZNF385B gene	27153756
D001151	Arsenic	Arsenic affects the methylation of ZNF385B gene	25304211
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased methylation of ZNF385B 5' UTR	29523930
D001379	Azathioprine	Azathioprine results in decreased expression of ZNF385B mRNA	22623647
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ZNF385B mRNA	20106945; 21632981;
C006780	bisphenol A	bisphenol A affects the methylation of ZNF385B intron	30906313
C006780	bisphenol A	bisphenol A results in decreased expression of ZNF385B mRNA	25181051
D002220	Carbamazepine	Carbamazepine affects the expression of ZNF385B mRNA	25979313
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ZNF385B mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with Resveratrol] results in increased expression of ZNF385B mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of ZNF385B mRNA	20106945; 25562108;
D000077209	Decitabine	Decitabine inhibits the reaction [Smoke results in decreased expression of ZNF385B mRNA]	21095227
C000944	dicrotophos	dicrotophos results in increased expression of ZNF385B mRNA	28302478
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of ZNF385B mRNA	29581250
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C118739	entinostat	entinostat results in decreased expression of ZNF385B mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of ZNF385B mRNA	30165855
D017313	Fenretinide	Fenretinide results in increased expression of ZNF385B mRNA	28973697
C042720	mercuric bromide	mercuric bromide results in decreased expression of ZNF385B mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ZNF385B mRNA	28001369
D009532	Nickel	Nickel results in decreased expression of ZNF385B mRNA	24768652; 25583101;
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D000077767	Panobinostat	Panobinostat results in decreased expression of ZNF385B mRNA	26272509
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of ZNF385B mRNA	26272509
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ZNF385B mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in decreased expression of ZNF385B mRNA	23557933
D011794	Quercetin	Quercetin results in decreased expression of ZNF385B mRNA	21632981
D000077185	Resveratrol	[Coumestrol co-treated with Resveratrol] results in increased expression of ZNF385B mRNA	19167446
D012906	Smoke	Decitabine inhibits the reaction [Smoke results in decreased expression of ZNF385B mRNA]	21095227
D012906	Smoke	Smoke results in decreased expression of ZNF385B mRNA	21095227
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ZNF385B mRNA	20106945; 21632981;
D014212	Tretinoin	Tretinoin results in decreased expression of ZNF385B mRNA	23724009
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of ZNF385B mRNA	24935251; 26272509;
C012589	trichostatin A	trichostatin A results in increased expression of ZNF385B mRNA	24935251
D014260	Triclosan	Triclosan results in decreased expression of ZNF385B mRNA	30510588
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ZNF385B mRNA	29024780
D014520	Urethane	Urethane results in decreased expression of ZNF385B mRNA	28818685
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ZNF385B mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ZNF385B mRNA	23179753; 24383497; 24935251; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ZNF385B gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ZNF385B mRNA	24935251
D000077337	Vorinostat	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF385B mRNA	27188386
D000077337	Vorinostat	Vorinostat results in decreased expression of ZNF385B mRNA	26272509
D000077337	Vorinostat	Vorinostat results in increased expression of ZNF385B mRNA	27188386
D000077211	Zoledronic Acid	Zoledronic Acid results in decreased expression of ZNF385B mRNA	24714768

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0053	Apoptosis
KW-0479	Metal-binding
KW-0539	Nucleus
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0677	Repeat
KW-0862	Zinc
KW-0863	Zinc-finger

Interpro

InterPro ID	InterPro Term
IPR003604	Matrin/U1-like-C_Znf_C2H2
IPR036236	Znf_C2H2_sf
IPR013087	Znf_C2H2_type

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term

Gene: ZNF385B

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction