Gene: Znf385b

Basic information

Tag Content
Uniprot ID Q8BXJ8; Q8BWQ7;
Entrez ID 241494
Genbank protein ID BAC34170.1; BAE28828.1; BAC32874.1;
Genbank nucleotide ID NM_001113400.1; NM_178723.6; NM_001113399.1;
Ensembl protein ID ENSMUSP00000107461; ENSMUSP00000088271; ENSMUSP00000107462;
Ensembl nucleotide ID ENSMUSG00000027016
Gene name Zinc finger protein 385B
Gene symbol Znf385b
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description May play a role in p53/TP53-mediated apoptosis.
Sequence
MNMATFLRGF EEKGLKNDRP GDQFSKEKKK ILFSFCEVCN IQLNSAAQAQ VHYDGKSHRK 60
RVKQLSDGQP PPPVQGSVPL LAGPCPCPGP GPNTSTGSAC HTTTLPALVR TPTLMMQPSL 120
DIKPFMSFPV DSSSAVGLFP NFNTMDPVQK AVINHTFGVS IPPKKKQVIS CNVCQLRFNS 180
DSQAEAHYKG SKHAKKVKAL EATKNKPKMV PSKDSAKANP SCSIRPGTGD SSDKSEDKGK 240
IKATSSSQPS GSEGGSFLLK SGTTPLPLGA IASPSKSTNG APGSVAESEE EKAKKLLYCS 300
LCKVAVNSLS QLEAHNTGSK HKTMVEARNG AGPIKSYPRP GSRLKVQNGS KGSGLQNKMF 360
HCEICDVHVN SEIQLKQHIS SRRHKDRVAG KPLKPKYSPY NKLQRSPSIL AAKLAFQKDL 420
MKPLAPTFLS SPLAAAAVSS ALSLPPRPSA SLFQAAAIPP ALLRPGHGPI RATPASILFA 480
PY 482

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZNF385B613328A4FUW9Bos taurusPredictionMore>>
1:1 orthologZNF385BA0A452FYI9Capra hircusPredictionMore>>
1:1 orthologZNF385B151126Q569K4CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologZnf385b241494Q8BXJ8Mus musculusPredictionMore>>
1:1 orthologZfp385bA0A0G2K4A6Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0002039 p53 bindingISO
GO:0003676 nucleic acid bindingIEA
GO:0008270 zinc ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorISS
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISS
GO:0005634 nucleusISO
GO:0005634 nucleusIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0053 Apoptosis
KW-0479 Metal-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0677 Repeat
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term