| Tag | Content |
|---|---|
| Uniprot ID | Q5RHR6 |
| Entrez ID | 566474 |
| Genbank protein ID | CAN88284.1; CAI11664.2; CAI20996.2; |
| Genbank nucleotide ID | NM_001100023.1 |
| Ensembl protein ID | ENSDARP00000122813; ENSDARP00000061167; |
| Ensembl nucleotide ID | ENSDARG00000041734 |
| Gene name | Protein broad-minded |
| Gene symbol | tbc1d32 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Required for high-level Shh responses in the developing neural tube. Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling. |
| Sequence | MSQFSTEDEA ELQTLLRKLL KSVKDRISGA PSVECAEEIL LHLEETDKNF HNYEFVKYLR 60 EYVESSLGAV IEVETENFTK GEGHAVGSGQ DTLVHAVTKN TRESTQYKQM MQTLKQTMMM 120 VVESLINKFE EDQMKREEMD RKIQHQQSIS QYADNCSDSD SSFNQSYAFI KHEQLQVIAE 180 KLDPGRPREV RWEALQSLCH APPSDVLSCE SWTGLRRNLS TALTDPDPEL SDKVLQFFAK 240 TFSSSPLNVT KDIYASIGNT KTLEAHFLYH KLSFPSGTTS IDANRPDMAR LLKQMRLMND 300 FQKEVTTFWI RHPEKYMEEI IENTLSLLAL HSEQGMSSPG SEKSLEPIHL ISLLDIKATW 360 FKKWMHGYYS RTVVLRLLER KYKSLIVNAL QQCIYYFDSC DALSEETLEM IHSLEHQQIG 420 PAGRTLYTSK ELEFVYFVHS LCVLGRLVMY TNGRKFFPIK VKKRRDPVTL TDLVVILINI 480 MYQHPKPSCG ETALADTMSP TNLVMEVLRT LCDRTECAVE CLYQIPVIET LLAPLITLLT 540 GKLPKLNSME SALTHTADTL ARIATTERGL SLLLYDRNLV SAEGESISAA HLIVQFTQKL 600 LAKELQVENS SSMSGAFIFV CRQMYNTCEG LQVLRPYSLH ECIAQAWRTT SSMSERVPTP 660 VPGAPPALAS QELQSVVAWE EMLLDNLLNF AATPKGLLLL QQTGAINECV TYMFSRFTKK 720 LQVSRCEKFG YGVMVTQVAT TAPGIVALQS SGFVQTIVVE LWSALECGRE DVRVVHPKST 780 PMDPIDRSCL KSFLSLVNLL SSPHAVWELL GHRALPNKTE YNLREMATSV LDLMDRLIII 840 NSDAKIHSLF NYEQSHTFGL RLLSVLCCNL DSFLLLESQY KLTDLLLQGQ RDNVTEPPSG 900 EGEFIIDGLS VERNHILVRI CAVGGPSERK LPPRALQKGN DPYPWPMVST YPLPKYYIFD 960 VPKILRTKQE SEIGAFLTSS KETERDASWM DDCRRQFCKI MATKSNTLTG YVLADLLEMV 1020 VLHLSSSSND CFFPPAEYKV VDNSVKTRSL SSVEQLGVEI SLRYGKFLKL LREDSEQDLC 1080 LLLKHCQEFL SQQRVKVTSE LCGYPGHDWF ASTVFLLMHG DVGRSLSLLL RFSRLLPSAF 1140 LWPPRLHSSV HLPIEIAQSA IHPIYSCTAH YVEMLLKAEV PLVFSAFRMS GFTPSQICVQ 1200 WLGQCFWNYL DWPEICQYVT TCVIMGPDYQ VYMCVSALRH LQQDILQHTQ TQDLQVFLKE 1260 EPIQGFRVSN YLEYMEGLER SYRSMVLSDM RSILPRSS 1298 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBC1D32 | F1PS18 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TBC1D32 | A0A452FLC7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBC1D32 | 221322 | Q96NH3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbc1d32 | 544696 | Q3URV1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBC1D32 | 472114 | A0A2I3TUU2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TBC1D32 | 100156680 | F1SF42 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tbc1d32 | D4A050 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tbc1d32 | 566474 | Q5RHR6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0035082 | axoneme assembly |
| GO:0060271 | cilium assembly |
| GO:0007275 | multicellular organism development |
| GO:1905515 | non-motile cilium assembly |
| Pfam ID | Pfam Term |
|---|---|
| PF14961 | BROMI |