| Tag | Content |
|---|---|
| Uniprot ID | Q62904 |
| Entrez ID | 29540 |
| Genbank protein ID | AAC52623.1 |
| Genbank nucleotide ID | NM_017235.3 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | 3-keto-steroid reductase |
| Gene symbol | Hsd17b7 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Responsible for the reduction of the keto group on the C-3 of sterols. |
| Sequence | MRKVVLITGA SSGIGLALCG RLLAEDDDLH LCLACRNLSK AGAVRDALLA SHPSAEVSIV 60 QMDVSNLQSV VRGAEEVKRR FQRLDYLYLN AGIMPNPQLN LKAFFCGIFS RNVIHMFSTA 120 EGLLTQNDKI TADGFQEVFE TNLFGHFILI RELEPLLCHS DNPSQLIWTS SRNAKKSNFS 180 LEDIQHAKGQ EPYSSSKYAT DLLNVALNRN FNQKGLYSSV TCPGVVMTNL TYGILPPFVW 240 TLLLPVIWLL RFFAHAFTVT PYNGAEALVW LFHQKPESLN PLTKYLSGTT GLGTNYVKGQ 300 KMDVDEDTAE KFYKTLLELE KQVRITIQKS DHHS 334 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HSD17B7 | 505212 | A4FUD2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HSD17B7 | 609364 | E2RNT4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HSD17B7 | 102179058 | A0A452DSV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HSD17B7 | 51478 | P56937 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hsd17b7 | 15490 | O88736 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HSD17B7 | H2Q1T6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | HSD17B7 | F1S213 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hsd17b7 | 29540 | Q62904 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hsd17b7 | 768185 | Q08BC5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005783 | endoplasmic reticulum |
| GO:0016021 | integral component of membrane |
| GO:0016020 | membrane |
| GO:0005886 | plasma membrane |
| GO:0000253 | 3-keto sterol reductase activity |
| GO:0004303 | estradiol 17-beta-dehydrogenase activity |
| GO:0005148 | prolactin receptor binding |
| GO:0030154 | cell differentiation |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0048706 | embryonic skeletal system development |
| GO:0006703 | estrogen biosynthetic process |
| GO:0021766 | hippocampus development |
| GO:0060135 | maternal process involved in female pregnancy |
| GO:0007399 | nervous system development |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0014070 | response to organic cyclic compound |
| GO:1990637 | response to prolactin |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0903 | Direct protein sequencing |
| KW-0325 | Glycoprotein |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0520 | NAD |
| KW-0521 | NADP |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00106 | adh_short |