| Tag | Content |
|---|---|
| Uniprot ID | Q64323; Q6LD71; Q8CCQ6; |
| Entrez ID | 18700 |
| Genbank protein ID | BAC27792.1; AAP32009.1; BAA05047.1; BAA06663.1; |
| Genbank nucleotide ID | XM_017318428.1; NM_011081.2; |
| Ensembl protein ID | ENSMUSP00000033754; ENSMUSP00000107874; |
| Ensembl nucleotide ID | ENSMUSG00000031381 |
| Gene name | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein |
| Gene symbol | Piga |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 10377440; 31232685; |
| Functional description | Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. |
| Sequence | MANRRGGGQG QPPSVSPSPG SSGNLSDDRT CTHNICMVSD FFYPNMGGVE SHIYQLSQCL 60 IERGHKVITV THAYGNRKGV RYLTNGLKVY YLPLRVMYNQ STATTLFHSL PLLRYIFVRE 120 RITIIHSHSS FSAMAHDALF HAKTMGLQTV FTDHSLFGFA DVSSVLTNKL LTVSLCDTNH 180 IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSVITVV VVSRLVYRKG 240 TDLLSGIIPE LCQKYQELHF LIGGEGPKRI ILEEVRERYQ LHDRVQLLGA LEHKDVRNVL 300 VQGHIFLNTS LTEAFCMAIV EAASCGLQVV STKVGGIPEV LPESLIILCE PSVKSLCDGL 360 EKAIFQVKSG TLPAPENIHN VVKTFYTWRN VAERTEKVYE RVSKETVLPM HKRLDRLISH 420 CGPVTGYMFA LLAVLSYLFL IFLQWMTPDS FIDVAIDATG PRRAWTHQWP RDKKRDENDK 480 ISQSR 485 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PIGA | 102187116 | A0A452F3Q4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PIGA | 5277 | P37287 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Piga | 18700 | Q64323 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PIGA | A0A2I3TBL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PIGA | F1SQU5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PIGA | 103351771 | A0A5F9CR14 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Piga | 363464 | D4AAY7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | piga | 791759 | B0S6Z8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006506 | GPI anchor biosynthetic process | IEA |
| GO:0006506 | GPI anchor biosynthetic process | IBA |
| GO:0006506 | GPI anchor biosynthetic process | IMP |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | ISS |
| GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | ISO |
| GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | IBA |
| GO:0005789 | endoplasmic reticulum membrane | ISS |
| GO:0005789 | endoplasmic reticulum membrane | ISO |
| GO:0016021 | integral component of membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162710 | Synthesis of glycosylphosphatidylinositol (GPI) | IEA |
| R-MMU-163125 | Post-translational modification: synthesis of GPI-anchored proteins | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |