| Tag | Content |
|---|---|
| Uniprot ID | Q6P0J3; Q6ED30; |
| Entrez ID | 324931 |
| Genbank protein ID | AAU04513.1; AAS16485.1; AAH65597.1; |
| Genbank nucleotide ID | XM_005157959.3; NM_205550.2; |
| Ensembl protein ID | ENSDARP00000101509; ENSDARP00000156612; |
| Ensembl nucleotide ID | ENSDARG00000056666 |
| Gene name | Transcription factor Sp8 |
| Gene symbol | sp8b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. |
| Sequence | MLAATCNKIG SPSPSPSSIS DNSSSFGKGF HPWKRATASS CSLGSSLSSF TRNGGGLSDS 60 FGTNTSTGSS AFSLTSGTSS NSHFGNDYSV FQTSVSNNSQ EPSHQPMFIS KVHTSVDSLQ 120 SIYPRMSVAH PYESWFKSSH PGIPTGDVGT TGASAWWDVG AGWIDVQNPN GAALQTSLHS 180 GGLQTSLHSP LGGYNSDYSS LSHSAFSTSA SPHLLTTGQH LMDGFKPVLS SYPDSSPSPL 240 GGAGGSMLTG GPTASLAGSP RSSARRYSGR ATCDCPNCQE AERLGPAGAS LRRKGLHSCH 300 IPGCGKVYGK TSHLKAHLRW HTGERPFVCN WLFCGKRFTR SDELQRHLRT HTGEKRFACP 360 VCNKRFMRSD HLSKHVKTHS AGGSSGSGSG ASGGKRGSDT DSEHSVPGSP SCHSPDLLQA 420 PESVPTTGMN GRASSLD 437 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SP8 | 102177029 | A0A452E4Z3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SP8 | 221833 | Q8IXZ3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sp8 | 320145 | Q8BMJ8 | CPO,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SP8 | 472642 | H2RBQ2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sp8 | 299499 | D3ZQL2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sp8b | 324931 | Q6P0J3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0003690 | double-stranded DNA binding |
| GO:0046872 | metal ion binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0035118 | embryonic pectoral fin morphogenesis |
| GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |