Gene: Sdccag8

Basic information

Tag Content
Uniprot ID Q80UF4
Entrez ID 76816
Genbank protein ID BAE21753.1; AAO27828.1; BAE21100.1;
Genbank nucleotide ID NM_029756.3
Ensembl protein ID ENSMUSP00000027785
Ensembl nucleotide ID ENSMUSG00000026504
Gene name Serologically defined colon cancer antigen 8 homolog
Gene symbol Sdccag8
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 25088364; 29444170;
Functional description Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062).
Sequence
MAKSPGNSTL EDSLGQYQRS LRERANRSIH QLKCALREVD VTVEEDALDP STSINVENED 60
TGVAWHELQH SHAVNQLKAL LRQQTNKENE TSPPRRRKLS PSRPSECDDG SMPTMHNLVP 120
IINDQSQYIH HLEAEVKFCK DELSGMKNRV QVVVLENERL QQELKSQRPE ETLREQTFLD 180
ASGNMQNSWI MTREDSRVDE AAKRPFSHGD AETGKTASTG DANKWKLELE RLKLTYEAKT 240
DLLESQLMLL RKDLAEYQKT CEDLKERLKH KESLLAASAS SRVGGLCLKC AQHEAVLSQT 300
HSNVHIQTIE RLTKERDDLM SVLVSVRSSL AEAQKRETSA YEQVKHAVQM TEEANFEKTK 360
ALIQCEQLKS ELERQTERLE KELASQQEKR AVEKEMIKKE VAREREDAES KMLILSQNIA 420
KLEAQVEKVT REKTAAVSHL EEIQNHVASQ EMDVTKVCGE MRFQLNKTKM EKDEVEKEHR 480
EYKAKSHKDL EMKVQEIEKL RLELSESEQH VEQEQQKAAR ARQECLRVTE LLGEAERQLH 540
LTRLEKDSIQ QSFSNEAKAQ ALQAQQREQE LTQKIQQMET QHDKTESEQY LLLTSQNTFL 600
TKLKEECCLL AKKLEKVSLK SRSQIVRLSQ EKRYLCDKLE KLQKRNDELE EQCIQHGRVH 660
ETMKERLRQL DKHGQATAQQ LVQLLNKQNQ LLLERQNLSE EVARLRAQLP SMPQSDC 717

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSDCCAG8102173768A0A452F279Capra hircusPredictionMore>>
1:1 orthologSDCCAG810806Q86SQ7Homo sapiensPredictionMore>>
1:1 orthologSdccag876816Q80UF4CPOMus musculusPublicationMore>>
1:1 orthologSDCCAG8469732K7C6J2Pan troglodytesPredictionMore>>
1:1 orthologA0A480L6N0Sus scrofaPredictionMore>>
1:1 orthologSDCCAG8100353951G1TAG0Oryctolagus cuniculusPredictionMore>>
1:1 orthologSdccag8A0A0G2JUD0Rattus norvegicusPredictionMore>>
1:1 orthologsdccag8A0A140TAU3Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0001764 neuron migrationIBA
GO:0001764 neuron migrationIMP
GO:0007098 centrosome cycleIEA
GO:0030010 establishment of cell polarityIMP
GO:0030010 establishment of cell polarityIBA
GO:0030030 cell projection organizationIEA
GO:0031023 microtubule organizing center organizationIBA
GO:0031023 microtubule organizing center organizationIMP
GO:0035148 tube formationIMP
GO:0035148 tube formationIBA
GO:1902017 regulation of cilium assemblyISO
GO:1902017 regulation of cilium assemblyIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005737 cytoplasmIDA
GO:0005813 centrosomeISO
GO:0005813 centrosomeIDA
GO:0005813 centrosomeIBA
GO:0005814 centrioleISS
GO:0005814 centrioleISO
GO:0005814 centrioleIBA
GO:0005814 centrioleIDA
GO:0005911 cell-cell junctionISO
GO:0034451 centriolar satelliteIDA
GO:0036064 ciliary basal bodyIDA
GO:0097733 photoreceptor cell ciliumIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1640170 Cell CycleIEA
R-MMU-1852241 Organelle biogenesis and maintenanceIEA
R-MMU-2565942 Regulation of PLK1 Activity at G2/M TransitionIEA
R-MMU-380259 Loss of Nlp from mitotic centrosomesIEA
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexesIEA
R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosomeIEA
R-MMU-380287 Centrosome maturationIEA
R-MMU-380320 Recruitment of NuMA to mitotic centrosomesIEA
R-MMU-453274 Mitotic G2-G2/M phasesIEA
R-MMU-5617833 Cilium AssemblyIEA
R-MMU-5620912 Anchoring of the basal body to the plasma membraneIEA
R-MMU-68877 Mitotic PrometaphaseIEA
R-MMU-68886 M PhaseIEA
R-MMU-69275 G2/M TransitionIEA
R-MMU-69278 Cell Cycle, MitoticIEA
R-MMU-8854518 AURKA Activation by TPX2IEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0965 Cell junction
KW-0966 Cell projection
KW-0970 Cilium biogenesis/degradation
KW-0175 Coiled coil
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR031887 SDCCAG8

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF15964 CCCAP

Protein-protein interaction

Protein-miRNA interaction