| Tag | Content |
|---|---|
| Uniprot ID | Q9ERZ6; Q3TPB0; Q3UP57; Q6PCM0; |
| Entrez ID | 60344 |
| Genbank protein ID | BAE37359.1; AAG17289.1; BAE25540.1; BAE37827.1; AAH59266.1; |
| Genbank nucleotide ID | NM_021716.5; NM_001267847.1; NM_001267846.1; |
| Ensembl protein ID | ENSMUSP00000122855 |
| Ensembl nucleotide ID | ENSMUSG00000075324 |
| Gene name | Fidgetin |
| Gene symbol | Fign |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 16751186 |
| Functional description | ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity). |
| Sequence | MISSTSVYGL KMQWTPEHAQ WPEQHFDITS TTRSPAHKVE AYRGHLQRTY QYAWANDDIS 60 ALTASNLLKK YAEKYSGILE GPVDRPVLSN YSDTPSGLVN GRKNDSEPWQ PSLNSEAVYP 120 MNCVPDVITA SKAGVSSALP PVDVSASIGS SPGVASNLTE PSYSSSTCGS HTVPSLHAGL 180 PSQEYAPGYN GSYLHSTYSS QATPALPSPH PSPLHSSGLL QPPPPPPPPP ALVPGYNGTS 240 NLSSYSYPSA SYPPQTAVGS GYSPGGAPPP PSAYLPSGIP APTPLPPTTV PGYTYQGHGL 300 TPIAPSALTN NSASSLKRKA FYMAGQGDMD SSYGNYSYGQ QRSTQSPMYR MPDNSISNSN 360 RGNGFDRNAE TSSLAFKPTK QLMPSEQQRK FSSQSSRALT PPSYSTAKNS LGSRSSESFG 420 KYTSPVMSEH GDDHRQLLAH PIQGPGLRAA TSSNHSVDEQ LKNTDTHLID LVTNEIITQG 480 PPVDWSDIAG LDLVKAVIKE EVLWPVLRSD AFSGLTALPR SILLFGPRGT GKTLLGRCIA 540 SQLGATFFKI AGSGLVAKWI GEAEKIIHAS FLVARCRQPS VIFVSDIDML LSSQVSEEHS 600 PVSRMRTEFL MQLDTVLTSA EDQIVVICAT SKPEEIDESL RRYFMKRLLI PLPDSTARHQ 660 IIVQLLTQHN YCLNDKEFAL LVQRTEGFSG LDVAHLCQEA AVGPLHAMPA TDLSAIMPSQ 720 LRPVTYQDFE NAFCKIQPSI SQKELDMYVE WNKMFGCSQ 759 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FIGN | 102182074 | A0A452F2S0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FIGN | 55137 | Q5HY92 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fign | 60344 | Q9ERZ6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FIGN | 470574 | A0A2I3SNC4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FIGN | A0A286ZU82 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FIGN | 100346621 | A0A5F9C299 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fign | 295649 | D3ZYS4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fign | F1QMW5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0008022 | protein C-terminus binding | IPI |
| GO:0008568 | microtubule-severing ATPase activity | IBA |
| GO:0016887 | ATPase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007049 | cell cycle | IEA |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | IBA |
| GO:0031122 | cytoplasmic microtubule organization | IBA |
| GO:0051013 | microtubule severing | IEA |
| GO:0051301 | cell division | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005815 | microtubule organizing center | IEA |
| GO:0005874 | microtubule | IEA |
| GO:0016363 | nuclear matrix | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| PROSITE ID | PROSITE Term |
|---|---|
| PS00674 | AAA |