| Tag | Content |
|---|---|
| Uniprot ID | Q9EST5; B1AVH9; Q566J4; |
| Entrez ID | 67628 |
| Genbank protein ID | BAE38387.1; BAB12436.1; AAH03489.1; AAH05628.1; AAH93506.1; |
| Genbank nucleotide ID | NM_130889.3 |
| Ensembl protein ID | ENSMUSP00000099990 |
| Ensembl nucleotide ID | ENSMUSG00000028333 |
| Gene name | Acidic leucine-rich nuclear phosphoprotein 32 family member B |
| Gene symbol | Anp32b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21636789 |
| Functional description | Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity). |
| Sequence | MDMKRRIHLE LRNRTPAAVR ELVLDNCKAM DGKIEGLTDE FVNLEFLSLI SVGLFSVSDL 60 PKLPKLKKLE LSENRIFGGL DRLAEELPSL THLNLSGNNL KDISTLEPLK RLDCLKSLDL 120 FGCEVTNRSD YRETVFRLLP QLSYLDGYDR EDQEAPDSDV EVDSVEEAPD SDGEVDGVDK 180 EEEDEEGEDE EEEEDEDGEE EEDEDEEDED EDEDVEGEDD EDEVSGEEEE FGHDGEVDED 240 EEDEDEDEDE EEEESGKGEK RKRETDDEGE DD 272 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ANP32B | A0A452EQC6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ANP32B | 10541 | Q92688 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Anp32b | 67628 | Q9EST5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ANP32B | 464605 | H2QXJ7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Anp32b | F1LP34 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | anp32b | 322000 | F1Q4N7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0042393 | histone binding | IBA |
| GO:0070063 | RNA polymerase binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | ISO |
| GO:0001944 | vasculature development | IMP |
| GO:0006334 | nucleosome assembly | IEA |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0021591 | ventricular system development | IMP |
| GO:0042981 | regulation of apoptotic process | IBA |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0045596 | negative regulation of cell differentiation | IEA |
| GO:0046827 | positive regulation of protein export from nucleus | IEA |
| GO:0048839 | inner ear development | IMP |
| GO:0060021 | roof of mouth development | IMP |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | IEA |
| GO:0005730 | nucleolus | IEA |
| GO:0005737 | cytoplasm | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|
| PROSITE ID | PROSITE Term |
|---|---|
| PS51450 | LRR |