Gene: Lmbr1

Basic information

Tag Content
Uniprot ID Q9JIT0; Q766D0; Q91WC6; Q9JIS9;
Entrez ID 56873
Genbank protein ID BAD07410.1; AAF91093.1; AAH16110.1; AAF91092.1;
Genbank nucleotide ID NM_020295.3
Ensembl protein ID ENSMUSP00000142755; ENSMUSP00000058405;
Ensembl nucleotide ID ENSMUSG00000010721
Gene name Limb region 1 protein
Gene symbol Lmbr1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 27933520.
Functional description Putative membrane receptor.
Sequence
MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE DEDAVVNRIS 60
LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL NGSLIHGLWN LASLFSNLCL 120
FVLMPFAFFF LESEGFAGLK KGIRARILET LVMLLLLALL ILGMVWVASA LIDSDAASME 180
SLYDLWEFYL PYLYSCISLM GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI 240
TLEEEALQRR LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL 300
LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL EIILIFYLMV 360
SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA LPVMSRTLGI TRFDLLGDFG 420
RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF TSAVREELFK ALGLHKLHLS DTSRDSETTK 480
PSANGHQKAL

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologLMBR1482819A0A5F4D5K8Canis lupus familiarisPredictionMore>>
1:1 orthologLMBR1A0A452EMH0Capra hircusPredictionMore>>
1:1 orthologLMBR1H0Y6V6Homo sapiensPredictionMore>>
1:1 orthologLmbr156873Q9JIT0CPOMus musculusPublicationMore>>
1:1 orthologLMBR1739991H2QZM6Pan troglodytesPredictionMore>>
1:1 orthologLMBR1A0A287BKQ1Sus scrofaPredictionMore>>
1:1 orthologLMBR1100352265G1SF20Oryctolagus cuniculusPredictionMore>>
1:1 orthologLmbr1A0A0G2K4B6Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004888 transmembrane signaling receptor activityIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0007165 signal transductionIBA
GO:0035116 embryonic hindlimb morphogenesisISO
GO:0042733 embryonic digit morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005887 integral component of plasma membraneIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0175 Coiled coil
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR008075 LIMR
IPR006876 LMBR1-like_membr_prot

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF04791 LMBR1

Protein-miRNA interaction