| Tag | Content |
|---|---|
| Uniprot ID | Q9JME2; Q9JJS2; |
| Entrez ID | 58250 |
| Genbank protein ID | BAA92942.1; CAB92141.1; |
| Genbank nucleotide ID | NM_021439.2 |
| Ensembl protein ID | ENSMUSP00000045349 |
| Ensembl nucleotide ID | ENSMUSG00000034612 |
| Gene name | Carbohydrate sulfotransferase 11 |
| Gene symbol | Chst11 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 28185240 |
| Functional description | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
| Sequence | MKPALLEVMR MNRICRMVLA TCFGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL 60 QELYNPIQLE LSNTAILHQM RRDQVTDTCR ANSAMSRKRR VLTPNDLKHL VVDEDHELIY 120 CYVPKVACTN WKRLMMVLSG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM 180 KFLFVREPFE RLVSAYRNKF TQKYNTSFHK RYGTKIIRRQ RKNATQEALR KGDDVKFEEF 240 VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVSGYLK 300 FPTYAKSTRT TDEMTTEFFQ NISAEHQTQL YEVYKLDFLM FNYSVPNYLK LD 352 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CHST11 | 528860 | F1N663 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CHST11 | 102184407 | A0A452EQU9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CHST11 | 100067989 | F7E238 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | CHST11 | 50515 | Q9NPF2 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Chst11 | 58250 | Q9JME2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CHST11 | A0A2I3TRV5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Chst11 | 314694 | P69478 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | chst11 | F1REP6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity | ISO |
| GO:0008146 | sulfotransferase activity | IDA |
| GO:0008146 | sulfotransferase activity | IBA |
| GO:0047756 | chondroitin 4-sulfotransferase activity | ISO |
| GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001701 | in utero embryonic development | IMP |
| GO:0002063 | chondrocyte development | IMP |
| GO:0007585 | respiratory gaseous exchange by respiratory system | IMP |
| GO:0009791 | post-embryonic development | IMP |
| GO:0016051 | carbohydrate biosynthetic process | IEA |
| GO:0030166 | proteoglycan biosynthetic process | IBA |
| GO:0030204 | chondroitin sulfate metabolic process | IMP |
| GO:0030206 | chondroitin sulfate biosynthetic process | ISO |
| GO:0030206 | chondroitin sulfate biosynthetic process | IDA |
| GO:0030206 | chondroitin sulfate biosynthetic process | IGI |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IMP |
| GO:0033037 | polysaccharide localization | IMP |
| GO:0036342 | post-anal tail morphogenesis | IMP |
| GO:0042127 | regulation of cell population proliferation | IMP |
| GO:0042733 | embryonic digit morphogenesis | IMP |
| GO:0043066 | negative regulation of apoptotic process | IMP |
| GO:0048589 | developmental growth | IMP |
| GO:0048703 | embryonic viscerocranium morphogenesis | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IMP |
| GO:0051216 | cartilage development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | IEA |
| GO:0016021 | integral component of membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-1630316 | Glycosaminoglycan metabolism | IEA |
| R-MMU-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | IEA |
| R-MMU-2022870 | Chondroitin sulfate biosynthesis | IEA |
| R-MMU-71387 | Metabolism of carbohydrates | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF03567 | Sulfotransfer_2 |