| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10746 |
Name | MAP3K2 |
Synonym | MEKK2|MEKK2B;mitogen-activated protein kinase kinase kinase 2;MAP3K2;mitogen-activated protein kinase kinase kinase 2 |
Definition | MAP/ERK kinase kinase 2|MAPK/ERK kinase kinase 2|MEK kinase 2|MEKK 2 |
Position | 2q14.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | MEKK2 signaling contributes to right ventricular hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced pulmonary hypertension. |
| More detail of all Mouse literatures about MAP3K2 | |
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Pathways and Diseases |
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Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Disease | Rheumatoid arthritis;FunDO |
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External Links |
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Links to Entrez Gene | 10746 |
Links to all GeneRIF Items | 10746 |
Links to iHOP | 10746 |
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Sequence Information |
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Nucleotide Sequence |
>10746 : length: 1860 atggatgatcagcaagctttgaactcaatcatgcaagatttggctgtccttcataaggcc agtcgaccagcattatccttgcaggaaaccagaaaagcaaaatcttcatcaccaaaaaaa cagaatgatgtccgagtcaaatttgaacatagaggagaaaaaagaatccttcagttcccc agaccagttaaactggaagatctgagatctaaagctaaaattgcctttggacagtctatg gatctacattataccaataacgagttggtaattccattaactactcaagatgacttggac aaagctgtggaactgctggatcgtagtattcatatgaagagcctcaagatattacttgta ataaatggaagtacacaggctactaatttagaaccattgccatcactagaagatttggat aatacagtatttggagcagagaggaaaaaacggctatctataataggtcctactagtaga gatagaagttctcctcccccaggttacattccagatgaattacaccaggttgcccggaat gggtcattcactagtatcaacagtgaaggagagttcattccagagagcatggaccaaatg ctggatccattatctttaagcagccctgaaaattctggctcaggaagttgtccatcactt gatagtcctttggatggagagagctatccaaaatcacgaatgcctagggctcagagctac ccagataatcatcaggaattttcagactatgataaccctatctttgagaaatttggaaaa ggaggaacatatccaagaaggtatcatgtttcatatcatcatcaagagtataatgatggt cgtaaaacttttccaagagctagaaggacccaggggaccagcttacggtctcctgtgagt ttcagtcctactgatcattccttaagcactagtagtggaagcagtatctttaccccagag tatgatgatagtcgaataagaagaaggggaagtgacatagacaatcctactttgaccgta atggacatcagcccacccagccgttcacctcgagctccgaccaactggagattgggcaaa ctgcttggccaaggagcctttggaagggtctacctctgttatgatgttgatacaggaaga gaattggctgttaagcaagttcaatttgaccccgatagtcctgagaccagcaaggaagta aatgcacttgagtgtgaaattcagttgctgaaaaacttgctacatgagcgaattgttcag tattatggctgtttgagggatccccaggaaaaaacactttccatatttatggaatatatg ccagggggttcaattaaggaccaattaaaagcatatggcgctcttactgagaatgtgact aggaaatacacccgtcagattctggagggtgtccattatttgcacagtaatatgattgtc catagagatatcaaaggcgcaaatatcctgcgagattcaacaggcaacgtcaaactagga gattttggggccagcaaacggcttcagaccatctgtctctcagggacaggaatgaagtct gtcacgggcacaccatactggatgagccctgaagtcatcagtggagaaggctatggaaga aaagcagacatctggagtgttgcatgtactgtggtagaaatgctaactgaaaagccgcct tgggctgaatttgaagcaatggctgccatctttaaaatcgccactcagccaacaaaccca aagctgccacctcatgtctcagactatactcgagatttcctcaaacggatttttgtagag gccaaactgagaccttcagctgatgaactcttaaggcacatgtttgtgcattatcactag |
Protein Sequence |
>10746 : length: 619 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE AKLRPSADELLRHMFVHYH |