| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 10746 |
Name | MAP3K2 |
Synonymous | MEKK2|MEKK2B;mitogen-activated protein kinase kinase kinase 2;MAP3K2;mitogen-activated protein kinase kinase kinase 2 |
Definition | MAP/ERK kinase kinase 2|MAPK/ERK kinase kinase 2|MEK kinase 2|MEKK 2 |
Position | 2q14.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr2:128056306-128146041 | chr2:128082232-128082232 | rs6430937 | Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Chromatin_Structure|FAIRE|Mcf7, Chromatin_Structure|FAIRE|H1hesc, Chromatin_Structure|FAIRE|Gm12878, Protein_Binding|ChIP-seq|CTCF | chr2:128056306-128146041 | chr2:128120286-128120286 | rs6735779 | Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Motifs|PWM|Pknox2, Chromatin_Structure|DNase-seq|Be2c, Protein_Binding|ChIP-seq|GATA2 | chr2:128056306-128146041 | chr2:128131762-128131762 | rs2139142 | Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|GATA6, Protein_Binding|ChIP-seq|HNF4A | chr2:128056306-128146041 | chr2:128137561-128137561 | rs4662724 | Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Single_Nucleotides|eQTL|MAP3K2, Motifs|Footprinting|HMGIY, Motifs|Footprinting|HMGIY, Motifs|PWM|HMGIY, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|DNase-seq|Gm19239 | chr2:128056306-128146041 | chr2:128144286-128144286 | rs7607907 | Single_Nucleotides|eQTL|MAP3K2, Protein_Binding|ChIP-seq|TRIM28 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
MEKK2(h) + MKK7(h) <==> MEKK2(h):MKK7(h) (binding) | MEKK2(h) + MKK7(h) + JNK1(h) <==> MEKK2(h):MKK7(h):JNK1(h) (binding) | 14-3-3sigma(m.s.) + MEKK2(h) <==> 14-3-3sigma(m.s.):MEKK2(h) (binding) | MAP3K2(h) --> MEKK2(h) (expression). | MKK7(h) + ATP --MEKK2(h)--> MKK7(h){p} + ADP (phosphorylation) | MAP3K2(h) --> MEKK2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
164 | Phosphoserine. | Swiss-Prot 53.0 | 304 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 331 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 524 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
There is no record for MAP3K2 | ||