| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10891 |
Name | PPARGC1A |
Synonym | LEM6|PGC-1(alpha)|PGC-1v|PGC1|PGC1A|PPARGC1;peroxisome proliferator-activated receptor gamma, coactivator 1 alpha;PPARGC1A;peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Definition | L-PGC-1alpha|PGC-1-alpha|PPAR gamma coactivator variant form|PPARGC-1-alpha|ligand effect modulator-6|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4|peroxisome proliferator-activated receptor gamma coactivator 1 |
Position | 4p15.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Decreased peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression was also associated with a net loss of mitochondrial protein and oxidative capacity. |
| More detail of all Human literatures about PPARGC1A | |
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Pathways and Diseases |
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Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | role of ppar-gamma coactivators in obesity and thermogenesis;PID BioCarta;100065 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | regulation of pgc-1a;PID BioCarta;100075 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Disease | lipids;GAD |
Disease | obesity;GAD |
Disease | cardiomyopathy hypertension left ventricular hypertrophy;GAD |
Disease | Breast cancer;FunDO |
Disease | Neoplasm metastasis;FunDO |
Disease | Metabolism disease;FunDO |
Disease | hypertension;GAD |
Disease | Diabetes Mellitus, Type 2;GAD |
Disease | Ventricular Dysfunction, Left;GAD |
Disease | Polycystic ovary syndrome;FunDO |
Disease | METABOLIC;GAD |
Disease | bone density;GAD |
Disease | diabetes, type 2;GAD |
Disease | intima media thickness;GAD |
Disease | endurance performance;GAD |
Disease | aerobic fitness insulin;GAD |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | insulin;GAD |
Disease | CANCER;GAD |
Disease | Rabies;FunDO |
Disease | NORMALVARIATION;GAD |
Disease | Birth Weight;GAD |
Disease | Hypertension;FunDO |
Disease | breast cancer;GAD |
Disease | Ovarian cancer;FunDO |
Disease | altered lipid oxidation and early insulin secretion;GAD |
Disease | Glucose intolerance;FunDO |
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External Links |
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Links to Entrez Gene | 10891 |
Links to all GeneRIF Items | 10891 |
Links to iHOP | 10891 |
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Sequence Information |
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Nucleotide Sequence |
>10891 : length: 2397 atggcgtgggacatgtgcaaccaggactctgagtctgtatggagtgacatcgagtgtgct gctctggttggtgaagaccagcctctttgcccagatcttcctgaacttgatctttctgaa ctagatgtgaacgacttggatacagacagctttctgggtggactcaagtggtgcagtgac caatcagaaataatatccaatcagtacaacaatgagccttcaaacatatttgagaagata gatgaagagaatgaggcaaacttgctagcagtcctcacagagacactagacagtctccct gtggatgaagacggattgccctcatttgatgcgctgacagatggagacgtgaccactgac aatgaggctagtccttcctccatgcctgacggcacccctccaccccaggaggcagaagag ccgtctctacttaagaagctcttactggcaccagccaacactcagctaagttataatgaa tgcagtggtctcagtacccagaaccatgcaaatcacaatcacaggatcagaacaaaccct gcaattgttaagactgagaattcatggagcaataaagcgaagagtatttgtcaacagcaa aagccacaaagacgtccctgctcggagcttctcaaatatctgaccacaaacgatgaccct cctcacaccaaacccacagagaacagaaacagcagcagagacaaatgcacctccaaaaag aagtcccacacacagtcgcagtcacaacacttacaagccaaaccaacaactttatctctt cctctgaccccagagtcaccaaatgaccccaagggttccccatttgagaacaagactatt gaacgcaccttaagtgtggaactctctggaactgcaggcctaactccacccaccactcct cctcataaagccaaccaagataacccttttagggcttctccaaagctgaagtcctcttgc aagactgtggtgccaccaccatcaaagaagcccaggtacagtgagtcttctggtacacaa ggcaataactccaccaagaaagggccggagcaatccgagttgtatgcacaactcagcaag tcctcagtcctcactggtggacacgaggaaaggaagaccaagcggcccagtctgcggctg tttggtgaccatgactattgccagtcaattaattccaaaacagaaatactcattaatata tcacaggagctccaagactctagacaactagaaaataaagatgtctcctctgattggcag gggcagatttgttcttccacagattcagaccagtgctacctgagagagactttggaggca agcaagcaggtctctccttgcagcacaagaaaacagctccaagaccaggaaatccgagcc gagctgaacaagcacttcggtcatcccagtcaagctgtttttgacgacgaagcagacaag accggtgaactgagggacagtgatttcagtaatgaacaattctccaaactacctatgttt ataaattcaggactagccatggatggcctgtttgatgacagcgaagatgaaagtgataaa ctgagctacccttgggatggcacgcaatcctattcattgttcaatgtgtctccttcttgt tcttcttttaactctccatgtagagattctgtgtcaccacccaaatccttattttctcaa agaccccaaaggatgcgctctcgttcaaggtccttttctcgacacaggtcgtgttcccga tcaccatattccaggtcaagatcaaggtctccaggcagtagatcctcttcaagatcctgc tattactatgagtcaagccactacagacaccgcacgcaccgaaattctcccttgtatgtg agatcacgttcaagatcgccctacagccgtcggcccaggtatgacagctacgaggaatat cagcacgagaggctgaagagggaagaatatcgcagagagtatgagaagcgagagtctgag agggccaagcaaagggagaggcagaggcagaaggcaattgaagagcgccgtgtgatttat gtcggtaaaatcagacctgacacaacacggacagaactgagggaccgttttgaagttttt ggtgaaattgaggagtgcacagtaaatctgcgggatgatggagacagctatggtttcatt acctaccgttatacctgtgatgcttttgctgctcttgaaaatggatacactttgcgcagg tcaaacgaaactgactttgagctgtacttttgtggacgcaagcaatttttcaagtctaac tatgcagacctagattcaaactcagatgactttgaccctgcttccaccaagagcaagtat gactctctggattttgatagtttactgaaagaagctcagagaagcttgcgcaggtaa |
Protein Sequence |
>10891 : length: 798 MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSD QSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTD NEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNP AIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKK KSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTP PHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSK SSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQ GQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADK TGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSC SSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSC YYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESE RAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFI TYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKY DSLDFDSLLKEAQRSLRR |