| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1950 |
Name | EGF |
Synonym | HOMG4|URG;epidermal growth factor;EGF;epidermal growth factor |
Definition | beta-urogastrone|pro-epidermal growth factor |
Position | 4q25 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Role of epidermal growth factor inhibition in experimental pulmonary hypertension. |
| More detail of all Human literatures about EGF | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | EGFR downregulation;PID Reactome;500515 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | EGFR-dependent Endothelin signaling events;PID Curated;200095 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | Signaling by EGFR;PID Reactome;500510 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | ErbB receptor signaling network;PID Curated;200136 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Arf6 signaling events;PID Curated;200060 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | Internalization of ErbB1;PID Curated;200146 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Disease | Hair morphology;NHGRI |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | Cytomegalovirus infection;FunDO |
Disease | Cancer;FunDO |
Disease | arrhythmia, cardiac;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | Keratosis;FunDO |
Disease | IMMUNE;GAD |
Disease | Infection;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | brain cancer;GAD |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | periodontitis;GAD |
Disease | Schizophrenia;FunDO |
Disease | Cirrhosis;FunDO |
Disease | malignant melanoma;GAD |
Disease | Drug abuse;FunDO |
Disease | PSYCH;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | hair morphology;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | Kidney failure;FunDO |
Disease | Hypomagnesemia 4, renal;OMIM |
Disease | Autistic disorder;FunDO |
Disease | Endometriosis;FunDO |
Disease | Birth Weight;GAD |
Disease | Necrotizing enterocolitis;FunDO |
Disease | Growth retardation;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | IGA glomerulonephritis;FunDO |
Disease | heart rate;GAD |
Disease | schizophrenia;GAD |
Disease | stomach cancer;GAD |
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External Links |
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Links to Entrez Gene | 1950 |
Links to all GeneRIF Items | 1950 |
Links to iHOP | 1950 |
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Sequence Information |
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Nucleotide Sequence |
>1950 : length: 3501 atgctgctcactcttatcattctgttgccagtagtttcaaaatttagttttgttagtctc tcagcaccgcagcactggagctgtcctgaaggtactctcgcaggaaatgggaattctact tgtgtgggtcctgcacccttcttaattttctcccatggaaatagtatctttaggattgac acagaaggaaccaattatgagcaattggtggtggatgctggtgtctcagtgatcatggat tttcattataatgagaaaagaatctattgggtggatttagaaagacaacttttgcaaaga gtttttctgaatgggtcaaggcaagagagagtatgtaatatagagaaaaatgtttctgga atggcaataaattggataaatgaagaagttatttggtcaaatcaacaggaaggaatcatt acagtaacagatatgaaaggaaataattcccacattcttttaagtgctttaaaatatcct gcaaatgtagcagttgatccagtagaaaggtttatattttggtcttcagaggtggctgga agcctttatagagcagatctcgatggtgtgggagtgaaggctctgttggagacatcagag aaaataacagctgtgtcattggatgtgcttgataagcggctgttttggattcagtacaac agagaaggaagcaattctcttatttgctcctgtgattatgatggaggttctgtccacatt agtaaacatccaacacagcataatttgtttgcaatgtccctttttggtgaccgtatcttc tattcaacatggaaaatgaagacaatttggatagccaacaaacacactggaaaggacatg gttagaattaacctccattcatcatttgtaccacttggtgaactgaaagtagtgcatcca cttgcacaacccaaggcagaagatgacacttgggagcctgagcagaaactttgcaaattg aggaaaggaaactgcagcagcactgtgtgtgggcaagacctccagtcacacttgtgcatg tgtgcagagggatacgccctaagtcgagaccggaagtactgtgaagatgttaatgaatgt gctttttggaatcatggctgtactcttgggtgtaaaaacacccctggatcctattactgc acgtgccctgtaggatttgttctgcttcctgatgggaaacgatgtcatcaacttgtttcc tgtccacgcaatgtgtctgaatgcagccatgactgtgttctgacatcagaaggtccctta tgtttctgtcctgaaggctcagtgcttgagagagatgggaaaacatgtagcggttgttcc tcacccgataatggtggatgtagccagctctgcgttcctcttagcccagtatcctgggaa tgtgattgctttcctgggtatgacctacaactggatgaaaaaagctgtgcagcttcagga ccacaaccatttttgctgtttgccaattctcaagatattcgacacatgcattttgatgga acagactatggaactctgctcagccagcagatgggaatggtttatgccctagatcatgac cctgtggaaaataagatatactttgcccatacagccctgaagtggatagagagagctaat atggatggttcccagcgagaaaggcttattgaggaaggagtagatgtgccagaaggtctt gctgtggactggattggccgtagattctattggacagacagagggaaatctctgattgga aggagtgatttaaatgggaaacgttccaaaataatcactaaggagaacatctctcaacca cgaggaattgctgttcatccaatggccaagagattattctggactgatacagggattaat ccacgaattgaaagttcttccctccaaggccttggccgtctggttatagccagctctgat ctaatctggcccagtggaataacgattgacttcttaactgacaagttgtactggtgcgat gccaagcagtctgtgattgaaatggccaatctggatggttcaaaacgccgaagacttacc cagaatgatgtaggtcacccatttgctgtagcagtgtttgaggattatgtgtggttctca gattgggctatgccatcagtaatgagagtaaacaagaggactggcaaagatagagtacgt ctccaaggcagcatgctgaagccctcatcactggttgtggttcatccattggcaaaacca ggagcagatccctgcttatatcaaaacggaggctgtgaacatatttgcaaaaagaggctt ggaactgcttggtgttcgtgtcgtgaaggttttatgaaagcctcagatgggaaaacgtgt ctggctctggatggtcatcagctgttggcaggtggtgaagttgatctaaagaaccaagta acaccattggacatcttgtccaagactagagtgtcagaagataacattacagaatctcaa cacatgctagtggctgaaatcatggtgtcagatcaagatgactgtgctcctgtgggatgc agcatgtatgctcggtgtatttcagagggagaggatgccacatgtcagtgtttgaaagga tttgctggggatggaaaactatgttctgatatagatgaatgtgagatgggtgtcccagtg tgcccccctgcctcctccaagtgcatcaacaccgaaggtggttatgtctgccggtgctca gaaggctaccaaggagatgggattcactgtcttgactctactccaccccctcacctcagg gaagatgaccaccactattccgtaagaaatagtgactctgaatgtcccctgtcccacgat gggtactgcctccatgatggtgtgtgcatgtatattgaagcattggacaagtatgcatgc aactgtgttgttggctacatcggggagcgatgtcagtaccgagacctgaagtggtgggaa ctgcgccacgctggccacgggcagcagcagaaggtcatcgtggtggctgtctgcgtggtg gtgcttgtcatgctgctcctcctgagcctgtggggggcccactactacaggactcagaag ctgctatcgaaaaacccaaagaatccttatgaggagtcgagcagagatgtgaggagtcgc aggcctgctgacactgaggatgggatgtcctcttgccctcaaccttggtttgtggttata aaagaacaccaagacctcaagaatgggggtcaaccagtggctggtgaggatggccaggca gcagatgggtcaatgcaaccaacttcatggaggcaggagccccagttatgtggaatgggc acagagcaaggctgctggattccagtatccagtgataagggctcctgtccccaggtaatg gagcgaagctttcatatgccctcctatgggacacagacccttgaagggggtgtcgagaag ccccattctctcctatcagctaacccattatggcaacaaagggccctggacccaccacac caaatggagctgactcagtga |
Protein Sequence |
>1950 : length: 1166 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS EGYQGDGIHCLDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYAC NCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQK LLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQA ADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEK PHSLLSANPLWQQRALDPPHQMELTQ |