| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 1950 |
Name | EGF |
Synonymous | HOMG4|URG;epidermal growth factor;EGF;epidermal growth factor |
Definition | beta-urogastrone|pro-epidermal growth factor |
Position | 4q25 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for EGF | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
EGF(h) --> PTGS2(h) (transactivation) | EGF(h) --> LKB1(r){pS431} (phosphorylation) | EGF(h) + ErbB1(h) <==> EGF(h):ErbB1(h) (binding) | EGF(h) + ErbB2(h) <==> EGF(h):ErbB2(h) (binding) | EGF(h) --adam10(m)--> EGF-ECD(h) + protein remnants (processing) | EGF(h) --> FOS(h) (transactivation) | EGF(h) --> FOSL1(h) (transactivation) | EGF(h) --> EGR1(h) (transactivation) | EGF(h) --> Egr1(m) (transactivation) | EGF(h) --> EGFR(h){pY} (increase of phosphorylation) | EGF(h) --> UBF(r){p} (increase of phosphorylation) | EGF(h) --> itch(h){p} (increase of phosphorylation) | EGF(h) --> EGFR(mo):Sos1(h) (increase of binding) | EGF(h) --> ERK2(m.s.){p} (increase of phosphorylation) | EGF(h) --> JNK(m.s.){p} (increase of phosphorylation) | EGF(h) --> AKT(m.s.){p} (increase of phosphorylation) | EGF(h) + ErbB1(m.s.):ErbB2(m.s.) <==> EGF(h):ErbB1(m.s.):ErbB2(m.s.) (binding) | EGF(h) --> dynamin(m){pY} (increase of phosphorylation) | EGF(h) --> caveolin-1(m){pY14} (increase of phosphorylation) | EGF(h) --> SRC(m){pY} (increase of phosphorylation) | EGF(h) --> caveolin-1(h){pY14} (increase of phosphorylation) | Egf(h) --> EGF(h) (expression). | H2O2 --> AKT(h) (activation) | EGF(h) --> STAT3(m.s.){pY705} (increase of phosphorylation) | EGF(h) + ErbB2(m.s.):ErbB4(m) <==> ErbB2(m.s.):EGF(h):ErbB4(m) (binding) | EGF(h) + (ErbB1(m.s.))2 <==> (ErbB1(m.s.))2:EGF(h) (binding) | EGF(h) --> c-Cbl(m){pY} (increase of phosphorylation) | EGF(h) --> Mapk(m){p} (increase of phosphorylation) | EGF(h) --> ERK1(r){p} (increase of phosphorylation) | EGF(h) --> ERK2(r){p} (increase of phosphorylation) | EGF(h) --> AT1receptor(r){p} (increase of phosphorylation) | EGF(h) --> caveolin-1(r){pY14} (increase of phosphorylation) | EGF(h) + ErbB2(h):ErbB1(h) <==> ErbB2(h):ErbB1(h):EGF(h) (binding) | EGF(h) + ErbB2(ha):ErbB1(h) <==> EGF(h):ErbB1(h):ErbB2(ha) (binding) | EGF(h) --> ERK1(h){pY} (increase of phosphorylation) | EGF(h) --> ERK2(h){pY} (increase of phosphorylation) | EGF(h) --> Shc-1-p46(h){pY} (increase of phosphorylation) | EGF(h) --> Shc-1-p52(h){pY} (increase of phosphorylation) | EGF(h) --> Shc-1(h):ErbB2(h) (increase of binding) | EGF(h) --> Shc-1(h):Grb-2(h) (increase of binding) | EGF(h) --> AKT-1(h){pS473} (increase of phosphorylation) | EGF(h) --> proCaspase-8(h){pY} (increase of phosphorylation) | EGF(h) --> Src(h){pY419} (increase of phosphorylation) | EGF(h) --> COX2(h) (increase of abundance) | EGF(h) --> C/EBPbeta(h) (increase of abundance) | EGF(h) --> C/EBPdelta(h) (increase of abundance) | EGF(h) --> c-Jun(h) (increase of abundance) | EGF(h) --> PTGS2(h) (transactivation) | EGF(h) --> CEBPD(h) (transactivation) | EGF(h) --> C/EBPdelta(h){sumo} (decrease of sumoylation) | EGF(h) --> C/EBPdelta(h){aceK} (increase of acetylation) | EGF(h) --> c-myc(h) (transactivation) | EGF(h) --> FOS(h) (transactivation) | EGF(h) --> MEK(pg){p} (increase of phosphorylation) | EGF(h) --> ERK1(m){pY} (increase of phosphorylation) | EGF(h) --> ERK2(m){pY} (increase of phosphorylation) | EGF(h) --> ERK2(ha){pY} (increase of phosphorylation) | EGF(h) --> p66Shc(ha){pY} (increase of phosphorylation) | EGF(h) --> p52Shc(ha){pY} (increase of phosphorylation) | EGF(h) --> p46Shc(ha){pY} (increase of phosphorylation) | EGF(h) --> SRCASM(h){pY} (increase of phosphorylation) | EGF(h) --> ERK(r){p} (increase of phosphorylation) | EGF(h) --> p38(r){p} (increase of phosphorylation) | EGF(h) --> MEK(r){p} (increase of phosphorylation) | EGF(h) --/ p38(h) (decrease of abundance) | EGF(h) --> ERK(h){pY} (increase of phosphorylation) | EGF(h) --> STAT3(h){pY705} (increase of phosphorylation) | EGF(h) --> ATF-1(h){pS63} (increase of phosphorylation) | EGF(h) --> ERK(h){p} (increase of phosphorylation) | EGF(h) --> JNK(h){p} (increase of phosphorylation) | EGF(h) --> eps15(mo){ub} (increase of ubiquitination) | EGF(h) --> STAT5A(m){pY} (increase of phosphorylation) | EGF(h) --> STAT5B(m){pY} (increase of phosphorylation) | EGF(h) --> STAT5(m){pY} (decrease of phosphorylation) | EGF(h) --> Jak2(m){pY} (decrease of phosphorylation) | EGF(h) --> prlr(m){pY} (decrease of phosphorylation) | EGF(h) --> PTP-PEST(m) (increase of abundance) | EGF(h) --> Jak2(m):PTP-PEST(m) (increase of binding) | EGF(h) --> Cas(m){pY} (decrease of phosphorylation) | EGF(h) --> p70S6K1-alpha2(h){pT389} (increase of phosphorylation) | EGF(h) --> ERK1(r){pT203}{pY205} (increase of phosphorylation) | EGF(h) --> ERK2(r){pT183}{pY185} (increase of phosphorylation) | EGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | EGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | EGF(h) --> RSK1(r){p} (increase of phosphorylation) | EGF(h) --> ErbB1(mo){pY} (increase of phosphorylation) | EGF(h) --> ERK(mo){pT}{pY} (increase of phosphorylation) | EGF(h) --> ERK1(h){p} (increase of phosphorylation) | EGF(h) --> ERK2(h){p} (increase of phosphorylation) | EGF(h) --> ErbB1(m){pY} (increase of phosphorylation) | EGF(h) --> ErbB1(h){pY} (increase of phosphorylation) | EGF(h) --> p300(h){p} (increase of phosphorylation) | EGF(h) --> p300(m.s.){p} (increase of phosphorylation) | EGF(h) --> cyclinD1(h) (increase of abundance) | EGF(h) --> cyclinE1(h) (increase of abundance) | EGF(h) --> p21Cip1(h) (increase of abundance) | EGF(h) --> AKT(h){p} (increase of phosphorylation) | EGF(h) --> STAT5B(h){pY699} (increase of phosphorylation) | EGF(h) --> cyclinD1(m) (increase of abundance) | EGF(h) --> cyclinE(m) (increase of abundance) | EGF(h) --> Cdk4(m) (increase of abundance) | EGF(h) --> Cdk2(m) (increase of abundance) | EGF(h) --> pRb(m) (increase of abundance) | EGF(h) --/ p21Cip1(m) (decrease of abundance) | EGF(h) --/ p27Kip1(m) (decrease of abundance) | EGF(h) --> GLUT1(m) (increase of abundance) | EGF(h) --> Ras(m) (increase of abundance) | EGF(h) --> Fos(m) (transactivation) | EGF(h) --> c-myc(m) (transactivation) | EGF(h) --> Jun(m) (transactivation) | EGF(h) --> gja1(m){p} (increase of phosphorylation) | EGF(h) --> p38(m){p} (increase of phosphorylation) | EGF(h) --> ERK1(m){p} (increase of phosphorylation) | EGF(h) --> ERK2(m){p} (increase of phosphorylation) | EGF(h) --> STAT5B(h){pY} (increase of phosphorylation) | EGF(h) --> MST1(m.s.){pT387} (increase of phosphorylation) | EGF(h) --> MST1(m.s.):AKT-1(m.s.) (increase of binding) | EGF(h) --> MST1(h):AKT-1(h) (increase of binding) | EGF(h) --> FOXO3a(h){pS} (decrease of phosphorylation) | EGF(h) --> histone H3(m){aceK10} (increase of acylation) | EGF(h) --> histone H3(m){met(3)K5}{met(3)K37} (increase of methylation) | EGF(h) --> s100a11(h) (increase of abundance) | EGF(h) --> Jak2(m){pS523} (increase of phosphorylation) | EGF(h) --> EGFR(h):c-Cbl(m.s.) (increase of binding) | EGF(h) --> c-Cbl(h){pY774} (increase of phosphorylation) | EGF(h) --> ERK2(m.s.){p} (increase of phosphorylation) | EGF(h) --> AKT-1(m.s.){pT308} (increase of phosphorylation) | EGF(h) --> FOXO1A(m.s.){pS256} (increase of phosphorylation) | EGF(h) --> Raf-1(h):Ras(h):GTP (increase of binding) | EGF(h) --> Ral(m.s.):Rap1(h):GTP (increase of binding) | EGF(h) --> EGFR(m.s.){pY} (increase of phosphorylation) | Egf(h) --> EGF(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
38 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 104 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 117 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 148 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 324 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 404 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 596 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 815 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 926 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
There is no record for EGF | ||